Protein Alignment Aldh and ALDH9A1

DIOPT Version :9

• Sequence 1: NP_001260290.1
• Gene: Aldh / 34256
• FlyBaseID: FBgn0012036
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000687.3
• Gene: ALDH9A1 / 223
• HGNCID: 412
• Length: 518
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 205/529 - (38%)
• Similarity: 308/529 - (58%)
• Gaps: 43/529 - (8%)

  Fly    10 LLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSG------------KIFETINP 62
            ||||...:..||::                ||.|:.::....:.|            |.||   |
Human    13 LLRSLRPSPVAAMS----------------TGTFVVSQPLNYRGGARVEPADASGTEKAFE---P 58

  Fly    63 TTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLET 127
            .|..|||...|:.::::::|||.|:.|||:   |.:....||.|:|...|.::...:..:|::|.
Human    59 ATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDEIATMEC 120

  Fly   128 LDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPI 192
            ::|||.. ....:|:..:.:.|.|:||.|....|:.|.:.|..|.|||.||:|||..|..||:|.
Human   121 INNGKSI-FEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPF 184

  Fly   193 LMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDV 257
            .:.:||..||||.||.:|.||:..|.::||.:|::..|||.|.|:.|||.|....|..|..|.||
Human   185 QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDV 249

  Fly   258 DKVAFTGSTDVG-KLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCC 321
            .||:||||...| |::::::  ..:|.||||||||||.||.||.||:.||:.|....|...||.|
Human   250 AKVSFTGSVPTGMKIMEMSA--KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVC 312

  Fly   322 CAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKL 386
            |.|:|.||:.:|.|:|.|...::.::..:|:|...:|..||.:|...:|::||.:|..|:||||:
Human   313 CNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKV 377

  Fly   387 VAGG-----SRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYG 446
            :.||     ..|:...||:::|.|..:.:||||..:|||||||..::.|....||:||||::.:|
Human   378 LCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 442

  Fly   447 LAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSV 511
            |||.|||:|:.:|:.:|..|:|||.::|.|||...:.||||||.||.|||||...:..|:::|:|
Human   443 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 507

  Fly   512 IVKVAQKNS 520
            .|::....|
Human   508 CVEMGDVES 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	202/519 (39%)
		ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	197/497 (40%)
ALDH9A1	NP_000687.3	ALDH_F9_TMBADH	55..512	CDD:143409	193/465 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810