DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALDH1A3

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_000684.2	Gene:	ALDH1A3 / 220	HGNCID:	409	Length:	512	Species:	Homo sapiens

Alignment Length:	494	Identity:	305/494 - (61%)
Similarity:	395/494 - (79%)	Gaps:	2/494 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFK 91
            :||:|....::.:|.:|||||||:|||||.|.|.||:|.|.|.|::..||.|:|.||:||:.||:
Human    19 ALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQ 83

  Fly    92 LGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWA 156
            .||||||:||..|||||::||||:|||:..||:|||:|.|||:..::.:||...|:.||||||||
Human    84 RGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWA 148

  Fly   157 DKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTA 221
            ||..|||||.|.:...:|||||:||||.|.|||||:||:.|||.|||..|||:||||||||.|||
Human   149 DKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTA 213

  Fly   222 LYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVT 285
            ||:..|:||||||.||||:||||| |.|||:::|..::|:||||||:||||::.|:..:||||||
Human   214 LYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVT 278

  Fly   286 LELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTV 350
            ||||||:|.|:.:|.|:|.|||.||.|:|||.||||.|.||.|||:::|.|||.||.|.||||.|
Human   279 LELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPV 343

  Fly   351 GNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTI 415
            |:|||:.||||||::::|.:|||.:|::|||:||||..|||..|. .|.|::||||::|.|:|.|
Human   344 GDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMED-KGLFIKPTVFSEVTDNMRI 407

  Fly   416 AREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLA 480
            |:||||||||.:::||.::|||:|||:::|||.||||||:||||..:...|.:||||:|.||.|.
Human   408 AKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALY 472

  Fly   481 AQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            |||||||:||||:|||.|||||:.|||||:|.:|:..||
Human   473 AQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	301/485 (62%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	299/480 (62%)
ALDH1A3	NP_000684.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		1/2 (50%)
ALDH1A3	NP_000684.2	ALDH_F1AB_F2_RALDH1	26..506	CDD:143459	299/480 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830