DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALDH1B1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_000683.3	Gene:	ALDH1B1 / 219	HGNCID:	407	Length:	517	Species:	Homo sapiens

Alignment Length:	522	Identity:	347/522 - (66%)
Similarity:	419/522 - (80%)	Gaps:	7/522 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTGAL-LRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTT 64
            |||.|....| |:.:...:::|.|    ||.|...|||.|..:||||||..:.|.|.|.|:||||
Human     1 MLRFLAPRLLSLQGRTARYSSAAA----LPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTT 61

  Fly    65 AEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLD 129
            .|||..:...|:.|:|.||:|||.||:|||||||||||||||||.|||||:|||:||||||||||
Human    62 GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLD 126

  Fly   130 NGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILM 194
            ||||:..||.:||...||..|||||||||.|||||||||..|.:||||||||||||||||||::|
Human   127 NGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVM 191

  Fly   195 MAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVD 258
            ..|||.||||||||:|:|.||||.|:|||:|.|:||||||.||||::.|:| |||||:|.|.|||
Human   192 QGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVD 256

  Fly   259 KVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCA 323
            ||||||||:||.|||.|:|::||||||||||||||:|:|:|.||::|||..|..|||||||||||
Human   257 KVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCA 321

  Fly   324 GSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVA 388
            |||||||:.||:||:||:.|:||:|.|||||:|:|:|||||::||.|::||.|:.|:|:||||:.
Human   322 GSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLC 386

  Fly   389 GGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFT 453
            ||.| .|..|:|::||||..|||||.||:||||||||.|.:|||::||:|||||:.|||||||||
Human   387 GGER-FGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFT 450

  Fly   454 KDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQK 518
            :|||||.|....|:||||||||||::....||||:|.||:|||.||..|..|||||:|.:||.||
Human   451 RDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQK 515

  Fly   519 NS 520
            ||
Human   516 NS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	336/504 (67%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	330/480 (69%)
ALDH1B1	NP_000683.3	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	330/480 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	703	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	736	1.000	Inparanoid score	I601
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm41659
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840