DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALDH2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_000681.2	Gene:	ALDH2 / 217	HGNCID:	404	Length:	517	Species:	Homo sapiens

Alignment Length:	522	Identity:	362/522 - (69%)
Similarity:	426/522 - (81%)	Gaps:	16/522 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLRSQA-------KNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEV 67
            :||:.|       :...:|.|. .::|.|...|::....:|||||||.:.|.|.|.|:||:|.||
Human     1 MLRAAARFGPRLGRRLLSAAAT-QAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEV 64

  Fly    68 IAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGK 132
            |.::...||||:|.||:|||.||:|||||||||||.|||||.|||||:|||:.|||:||||||||
Human    65 ICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGK 129

  Fly   133 PYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAW 197
            ||.:||.|||...:|.|||:||||||.||||||:|||||:|||||||||||||||||||:||.||
Human   130 PYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAW 194

  Fly   198 KLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVA 261
            ||||||||||.:|:|.||||.|||||:|.|:||||||.||||:||||| |||||:|:|.||||||
Human   195 KLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVA 259

  Fly   262 FTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSR 326
            |||||::|::||:|:|::|||||||||||||||||:||.|||:|||.|||.||||.|||||||||
Human   260 FTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSR 324

  Fly   327 TFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGS 391
            |||::.|||||||||..|||.|.||||||..|||||||:|.|.:||||.|.|||::||||:.||
Human   325 TFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGG- 388

  Fly   392 RPEGLP---GYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFT 453
               |:.   |||:|||||.||||.||||:|||||||.|:::||.::||:.|||||.|||||||||
Human   389 ---GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFT 450

  Fly   454 KDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQK 518
            ||||||||:...|:|||||||.|:|..||:|||||||||.|||.|||.|..|||||:|.|||.||
Human   451 KDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQK 515

  Fly   519 NS 520
            ||
Human   516 NS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	354/512 (69%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	348/483 (72%)
ALDH2	NP_000681.2	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	348/483 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159877
Domainoid	1	1.000	703	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55480
Inparanoid	1	1.050	736	1.000	Inparanoid score	I601
Isobase	1	0.950	-	0	Normalized mean entropy	S334
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm41659
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	LDO	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750