DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_705771.2	Gene:	Aldh1l2 / 216188	MGIID:	2444680	Length:	923	Species:	Mus musculus

Alignment Length:	503	Identity:	237/503 - (47%)
Similarity:	333/503 - (66%)	Gaps:	10/503 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAV 83
            |..|.:|.|......|..|.|. .|||.::..::.|:.:.|:|||....|..:..|...|:|.||
Mouse   423 AEMVVDYVSKEVNGMTVKIPYQ-CFINGQFVDAEDGETYATVNPTDGTTICRVSYASLADVDRAV 486

  Fly    84 QAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKN 148
            .||::||:.|. |.||:|.:||||:||||||||.:|..||::|.||:|..|:::....:..:::.
Mouse   487 AAAKDAFENGE-WGRMNARDRGRLMYRLADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQT 550

  Fly   149 LRYFAGWADKNHGKTIPMD----GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTI 209
            .||||||.||..|.|||::    ....|:|:.||:|.|..|||||:|::|:|||....||.|||:
Mouse   551 FRYFAGWCDKIQGSTIPINQARPNYNLTFTKKEPLGACAIIIPWNYPLMMLAWKSAACLAAGNTL 615

  Fly   210 VLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGF-GTAGAALANHCDVDKVAFTGSTDVGKLIQ 273
            |||||:.|.||||..|:|..:||||:||:|::||. |.||..|:.|.|:.|:.|||||.|||.|.
Mouse   616 VLKPAQVTPLTALKFAELTVKAGFPKGVINIIPGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIM 680

  Fly   274 LASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFV 338
            .:...:|||:|:||||||||.||.||.|::.||......:|||.|:.|.|..|.|||:.|:||||
Mouse   681 KSCAVSNLKKVSLELGGKSPLIIFSDCDLEKAVRMGMGAVFFNKGENCIAAGRLFVEEAIHDEFV 745

  Fly   339 ERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQP 403
            .|..|..||..:|:|.|.:|:.|||.:...:||:|...:||.::||.||.|| |....||:|::|
Mouse   746 TRVVEEIKKMKIGDPLDRSTDHGPQNHRAHLEKLLQYCETGVQEGATLVYGG-RQVQRPGFFMEP 809

  Fly   404 TVFADVQDDMTIAREEIFGPVQQLIRFKK--LDEVIERANNSEYGLAAAVFTKDLDKANYIVGGL 466
            |||..|:|.|.:|:||.|||:..:.:|:.  :|.|::||||:|||||:.|||:|::||.|:...|
Mouse   810 TVFTGVEDHMYLAKEESFGPIMVISKFQNGDIDGVLQRANNTEYGLASGVFTRDINKAMYVSDKL 874

  Fly   467 RAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            .||||::||||.....|||||.|.||.|::.||.||:.|.::|:|.::
Mouse   875 EAGTVFINTYNKTDVAAPFGGMKQSGFGKDLGEEALNEYLKIKTVTLE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	236/499 (47%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	233/486 (48%)
Aldh1l2	NP_705771.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..410	CDD:278949
		ALDH_F1L_FTFDH	438..923	CDD:143458	233/488 (48%)
		Aldehyde dehydrogenase	438..923		233/488 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820