DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and ALDH1A1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_000680.2	Gene:	ALDH1A1 / 216	HGNCID:	402	Length:	501	Species:	Homo sapiens

Alignment Length:	494	Identity:	322/494 - (65%)
Similarity:	401/494 - (81%)	Gaps:	2/494 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKL 92
            ||...|...|.||.:|||||||.|.|||.|...||.|.|.:.:::..||||:|.||:|||.||::
Human     9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQI 73

  Fly    93 GSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWAD 157
            |||||.|||||||||||:||||:|||::.||::|:::.||.||.:|..||...||.|||.|||||
Human    74 GSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138

  Fly   158 KNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTAL 222
            |..|:|||:||:|||||||||:||||||||||||::|:.||:||||:.|||:|:||||||.||||
Human   139 KIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTAL 203

  Fly   223 YIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTL 286
            ::|.|:||||||.||||:|||:| |||||:::|.|:|||||||||:|||||:.|:|.:|||||||
Human   204 HVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTL 268

  Fly   287 ELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVG 351
            |||||||.|:|:|.|:|.|||.||.|:|::.||||.|.||.|||:.||||||.||.|||||..:|
Human   269 ELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILG 333

  Fly   352 NPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIA 416
            ||......||||:::||.:|||.:|::|||:||||..||. |.|..|||||||||::|.|:|.||
Human   334 NPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG-PWGNKGYFVQPTVFSNVTDEMRIA 397

  Fly   417 REEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAA 481
            :|||||||||:::||.||:||:||||:.|||:|.|||||:|||..|...|:|||||||.|.|::|
Human   398 KEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSA 462

  Fly   482 QAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            |.||||:||||:|||.|||....|||||:|.||::||||
Human   463 QCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	315/484 (65%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	313/480 (65%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	313/480 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860