DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and alh-11

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001379574.1	Gene:	alh-11 / 185679	WormBaseID:	WBGene00000117	Length:	687	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	174/464 - (37%)
Similarity:	259/464 - (55%)	Gaps:	7/464 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMER 117
            |.:.||.|.|.:.:.:|....|.::.:|:.|:.|:.|.|   .|.:....||..:|.:..||::.
Worm   219 SDRKFEVIEPRSGKPMATWHYATRDQVDLTVKEAKKAQK---QWAKSSWMERSEILKKTGDLLKT 280

  Fly   118 DQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVC 182
            ....:|..|.:.||||.:.: ..|:.:.:....:::|.|....|:.:|:|...:.|||..||||.
Worm   281 HCNDIAYWECISNGKPIAEA-KADVLSCVDTFYFYSGIASDLLGQHVPLDASRYAYTRRLPVGVV 344

  Fly   183 GQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTA 247
            ..|..||:||...:||..||||.||.::.||:..:.:|||.:|:::|.||.|:||.||:.|....
Worm   345 AAIGAWNYPIQTCSWKTAPALACGNAVIYKPSPLSPVTALILAEILKSAGLPDGVFNVIQGDAET 409

  Fly   248 GAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFG 312
            ...|.:|..|.||:||||...||.|..|..:.|:|.|||||||||..|:..|.|:|.||..|...
Worm   410 AQDLIHHDGVSKVSFTGSIPTGKKIMKACADRNIKPVTLELGGKSALIVFDDADIDSAVSCAMMA 474

  Fly   313 LFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIK 377
            .|::.||.|...|:..|...:..||.::..:..:|..:|:|...:|:.|..::.|...|:.|.|.
Worm   475 NFYSQGQVCSNASKVLVHKSVLKEFTKKLVDHTQKMKIGDPLKEDTQVGSHISAEHRNKVEGYIS 539

  Fly   378 TGKKQGAKLVAGGSR--PEGLP-GYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIER 439
            |...:||..:.||.|  ..||. |:::.|.:...:...||:.||||||.|..:|.|...||.|:.
Worm   540 TAIAEGATKLCGGDRVAVHGLENGFYLSPCILTGITPKMTVYREEIFGSVLLIIPFDTEDEAIKI 604

  Fly   440 ANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSN 504
            ||:::.||||.:.||||.::..:...|.||.|:|||||.::...||||...||.|||||...|.:
Worm   605 ANDTDMGLAAGLVTKDLSRSYRVSEQLNAGNVYVNTYNDVSPLVPFGGVGESGFGRENGTAVLEH 669

  Fly   505 YTEVKSVIV 513
            ||.:|||.|
Worm   670 YTHLKSVFV 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	172/461 (37%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	174/464 (38%)
alh-11	NP_001379574.1	NLPC_P60	<30..131	CDD:419716
alh-11	NP_001379574.1	ALDH_F9_TMBADH	225..681	CDD:143409	171/458 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910