DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and alh-3

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_502054.2	Gene:	alh-3 / 177999	WormBaseID:	WBGene00000109	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	479	Identity:	206/479 - (43%)
Similarity:	301/479 - (62%)	Gaps:	9/479 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRL 107
            ||:.::..|..|:.|:||||.|.:.|.|:..|...|:|.||:||:.||:.|. ||:|.|.|||:.
Worm   431 FIDGKFVGSSDGRTFKTINPATEKPICELPLATVADVDRAVRAAKKAFERGE-WRQMSARERGKR 494

  Fly   108 LYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD----G 168
            ||:||:|||..:..||:||:||.|..|:::....:..:|...||||||.||..|||||:.    .
Worm   495 LYKLAELMEEHKEELATLESLDAGAVYTLALKTHVGMSIDVWRYFAGWCDKIQGKTIPISNARPN 559

  Fly   169 DFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGF 233
            .....|..||:||.|.|.|||:|::|::||:...||.|||:|.|||:.|.||||..|:|...||.
Worm   560 KNLCLTLREPIGVVGLITPWNYPLMMLSWKMAACLAAGNTVVHKPAQVTPLTALKFAELSVLAGI 624

  Fly   234 PEGVVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIIL 297
            |.||:|:|.|.|: .|..|..|.||.|:.|||||::|..:..:...:|:|:|:||||||||.||.
Worm   625 PPGVINIVTGSGSLVGNRLTAHPDVRKIGFTGSTEIGATVMESCAKSNIKKVSLELGGKSPLIIF 689

  Fly   298 SDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGP 362
            :|.|::.||:.|...:|||.|:.|.|..|.|:...|:|:||::..|.||:..:|:|.|.:|..||
Worm   690 ADADLEKAVKQACGAVFFNKGENCIAAGRVFIAKSIHDDFVKKLVEEAKQYQIGDPLDRSTAHGP 754

  Fly   363 QVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQL 427
            |.:...:.|::..::.....|||:..||.|.| ..|.:..||:.:::.|:...|.||.|||:..:
Worm   755 QNHLAHLNKLVEYVEKAVAGGAKVEVGGKRLE-REGLYFPPTILSNIDDENFAASEESFGPIMCV 818

  Fly   428 IRF--KKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKM 490
            ..|  ..:::|:.|||::|:||||.|||:|..|:..:...|.||||:||||......|||||:|.
Worm   819 SSFDDDDIEDVLRRANDTEFGLAAGVFTRDSSKSLRVAEALHAGTVFVNTYQKTDVAAPFGGFKQ 883

  Fly   491 SGHGRENGEYALSNYTEVKSVIVK 514
            ||.|::.||.||:.|...|::.::
Worm   884 SGFGKDMGEEALNEYLVTKTITIE 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	206/475 (43%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	206/477 (43%)
alh-3	NP_502054.2	fmt	1..318	CDD:273088
		FMT_core_FDH_N	1..209	CDD:187716
		FDH_Hydrolase_C	214..315	CDD:187731
		PP-binding	335..393	CDD:278949
		ALDH-SF	423..908	CDD:299846	206/479 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820