DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and alh-12

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001022930.1	Gene:	alh-12 / 176056	WormBaseID:	WBGene00000118	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	499	Identity:	187/499 - (37%)
Similarity:	272/499 - (54%)	Gaps:	27/499 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TTPDILYTGV-FINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPW 96
            |.|..|..|: |:|.:....:|.:.|:.|.|...:|:|:...|..:.:|..|:||.:|   .|.|
Worm     4 TVPSDLSGGLYFLNGKRTTIESTETFDVIEPRIGQVVAKCPKATADIVDQYVKAAADA---QSAW 65

  Fly    97 RRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHG 161
            ....|.:||::|:::|||:......:|..|...||||. .....|:.::.....:|.|.|
Worm    66 GETTALDRGKVLHKVADLIREHAEEIAIWEVKTNGKPI-YEARCDIASSADTFDFFGGIA----- 124

  Fly   162 KTIPMDGDF----------FTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQ 216
             |..:.||.          ..|||.||.||.|.|..||:|.....||:.||||.||.:|.||:..
Worm   125 -TAVLQGDSLELPGGPSQRIAYTRREPYGVVGCIGAWNYPFQTCVWKVAPALAAGNAVVYKPSPF 188

  Fly   217 TSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNL 281
            ...:.:.:.:::..||.|:||.||:.|...||.||..|..|.||:||||...|:.:|..:...|:
Worm   189 APASPVLLGEILTAAGVPKGVYNVIQGEQEAGVALCEHNLVAKVSFTGSVASGEAVQRQAATKNV 253

  Fly   282 KRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAK 346
            |.|||||||||..||..|:|:..||.:|....|.|.||.|...:|.||:..|...|.|...:.|.
Worm   254 KPVTLELGGKSEIIIFDDSDVKSAVASAMLANFLNQGQVCTNATRVFVQKGILASFTEAIVQEAN 318

  Fly   347 -KRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR--PEGLPG--YFVQPTVF 406
             |..||:|...:|..|..:||..:::|||.:::.|::|..::.||.|  |.|:.|  || :|.:.
Worm   319 DKLKVGDPLLEDTRVGANINEGHLQRILGYVESAKQEGGVVLRGGVRVHPTGVEGGAYF-EPAII 382

  Fly   407 ADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTV 471
            ..:.|:....||||||.|..::.|:..:|||.||||:.|||||.||:.:|.:.:.:...|:||||
Worm   383 TGLSDEARAVREEIFGAVMLILPFETEEEVIARANNTTYGLAAGVFSGNLARGHRVAARLQAGTV 447

  Fly   472 WVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKV 515
            ::||||......||||:|.|||||||....|..:|:.|::.|.|
Worm   448 FINTYNDTEVNVPFGGFKNSGHGRENCIDTLRAHTQTKAIYVNV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	185/494 (37%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	184/495 (37%)
alh-12	NP_001022930.1	ALDH_F9_TMBADH	31..492	CDD:143409	179/472 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910