DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and alh-9

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_498263.2	Gene:	alh-9 / 175820	WormBaseID:	WBGene00000115	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	155/531 - (29%)
Similarity:	248/531 - (46%)	Gaps:	49/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTG---ALLRSQ-AKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETIN 61
            |.|:|.:|   |.|::: |.......:.|..|.:...|.:  ..||| :.:|  :.||::.::..
Worm     1 MNRLLSSGMSAATLQTRMASQLLINDSKYGFLKELGLTEN--NAGVF-HGKW--AASGQVVQSFA 60

  Fly    62 PTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLE 126
            |.....||.:|..:.:|.:||:..|:.|:   :.|..:.|..||.::.::.|.:......|..|.
Worm    61 PANNSPIANVQNGNVQDYEIAISEAKKAY---NDWCEVPAPRRGEIVRQIGDKLRTQLQNLGKLV 122

  Fly   127 TLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTR--H------EPVGVCG 183
            :|:.||..:        ..:..::.:....|...|.:..::|..|...|  |      .|:||.|
Worm   123 SLEMGKISA--------EGVGEVQEYVDICDYATGLSRSLEGKIFPSERPGHALLEQWNPLGVVG 179

  Fly   184 QIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGV----VNVVPGF 244
            .|..:|||..:..|....||.|||::|.|||..|.|||:.:.:||:|......|    .::|.|.
Worm   180 VISAFNFPCAVYGWNNALALVTGNSVVWKPAPSTPLTAIAVTKLVEEVLVANNVNPALCSLVCGE 244

  Fly   245 GTAGAALANHCDVDKVAFTGSTDVGKL----IQLASGNTNLKRVTLELGGKSPNIILSDTDMDYA 305
            |..|.||.....|:.|:||||:::||:    :|...|     ::.|||||.:..|:..|.|::..
Worm   245 GDVGQALVKDKRVNLVSFTGSSEIGKIVGQQVQARFG-----KLLLELGGNNAIIVNEDADLNMV 304

  Fly   306 VETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVER--SAERAKKRTVGNPFDLNTEQGPQVNEEQ 368
            |....|......||.|....|..|.||:||:.:||  .|....:..:|.|.|.||..||..|::.
Worm   305 VPATVFAAVGTAGQRCTTTRRLIVHDKVYDQVLERLKKAYAQFESRIGCPLDSNTIIGPLHNQQA 369

  Fly   369 MEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKL 433
            :.|....:......|.|:..||...| ..|.||.||:...::.|..:...|.|.|:..:::|..|
Worm   370 VGKYKASVAEAVASGGKIEYGGKVLE-RDGNFVLPTIVTGLKHDSPVVLRETFAPILYVLKFSTL 433

  Fly   434 DEVIERANNSEYGLAAAVFTKDLDKANYIVG--GLRAGTVWVN--TYNVLAAQAPFGGYKMSGHG 494
            :|.|...|..:.||::::||.::......:|  |...|.|.||  |.......| |||.|.:|.|
Worm   434 EEAIAINNEVDQGLSSSLFTTNIQNVFKWMGPKGSDCGIVNVNIPTSGAEIGGA-FGGEKETGGG 497

  Fly   495 RENGEYALSNY 505
            ||:|..:...|
Worm   498 RESGSDSWRQY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	151/520 (29%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	146/494 (30%)
alh-9	NP_498263.2	ALDH_F7_AASADH	43..519	CDD:143448	145/487 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810