DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and alh-1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_498081.2	Gene:	alh-1 / 175691	WormBaseID:	WBGene00000107	Length:	510	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	331/518 - (63%)
Similarity:	416/518 - (80%)	Gaps:	15/518 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLRS------QAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVI 68
            :|||      ||:|.:......|:: :||      |||:|||||:..:||||.||||||...:|:
Worm     1 MLRSALRATVQARNASGVPPGLSNM-KPQ------YTGIFINNEFVPAKSGKTFETINPANGKVL 58

  Fly    69 AEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKP 133
            |::...||.|::|||:||:|||::||.|||||||:||.||.|||||||||:|.|||||:||||||
Worm    59 AQVAEGDKTDVNIAVKAAQNAFRIGSEWRRMDASQRGVLLNRLADLMERDRVILASLESLDNGKP 123

  Fly   134 YSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWK 198
            |:::||.|||.:||.|||:|||||||||||||::||:|||||||||||||||||||||:||.|||
Worm   124 YAVAYNADLPLSIKTLRYYAGWADKNHGKTIPIEGDYFTYTRHEPVGVCGQIIPWNFPLLMQAWK 188

  Fly   199 LGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAF 262
            ||||||.|||:|:|.||||.|:||::|.|.||||||:||||::||:| |||.|:::|.|||||||
Worm   189 LGPALAMGNTVVMKVAEQTPLSALHVAALTKEAGFPDGVVNIIPGYGHTAGQAISSHMDVDKVAF 253

  Fly   263 TGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRT 327
            ||||:||:|:..|:..:|:|:|||||||||||||.:|.|::.:|..|:.|||||.||||||||||
Worm   254 TGSTEVGRLVMKAAAESNVKKVTLELGGKSPNIIFADADLNDSVHQANHGLFFNQGQCCCAGSRT 318

  Fly   328 FVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR 392
            |||.||||:||.||.|.|:|..:|:||||.|.|||||:.:|:|.||..|..|||.||:||.||::
Worm   319 FVEGKIYDDFVARSKELAEKAVIGDPFDLKTTQGPQVDGKQVETILKYIAAGKKDGAQLVTGGAK 383

  Fly   393 PEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLD 457
             .|..|:||:||:||:|:|.||||:|||||||..:|||..::|::|:|||:.|||||.|.|||:|
Worm   384 -HGDQGHFVKPTIFANVKDQMTIAQEEIFGPVMTIIRFDTMEELVEKANNTIYGLAAGVMTKDID 447

  Fly   458 KANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            ||.:|....|||:||||.|:|..|.|||||:|.||.|||.|||.|..|||||:|.:||.||||
Worm   448 KALHIANATRAGSVWVNCYDVFDAAAPFGGFKQSGIGRELGEYGLEAYTEVKTVTIKVPQKNS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	324/508 (64%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	316/480 (66%)
alh-1	NP_498081.2	ALDH_F1AB_F2_RALDH1	24..504	CDD:143459	318/487 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	639	1.000	Domainoid score	I76
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55480
Inparanoid	1	1.050	673	1.000	Inparanoid score	I375
Isobase	1	0.950	-	0	Normalized mean entropy	S334
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm14082
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	LDO	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930