DRSC/TRiP Functional Genomics Resources

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Protein Alignment Aldh and ALDH1L2

DIOPT Version :10

Sequence 1:NP_609285.1 Gene:Aldh / 34256 FlyBaseID:FBgn0012036 Length:520 Species:Drosophila melanogaster
Sequence 2:NP_001029345.2 Gene:ALDH1L2 / 160428 HGNCID:26777 Length:923 Species:Homo sapiens


Alignment Length:479 Identity:232/479 - (48%)
Similarity:328/479 - (68%) Gaps:9/479 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 FINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRL 107
            |||.::..:..||.::|||||....|.::..|...|:|.||.||::||:.|. |.||:|.|||||
Human   446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMNARERGRL 509

  Fly   108 LYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD----G 168
            :||||||:|.:|..||::|.||:|..|:::....:..:::..||||||.||..|.|||::    .
Human   510 MYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPN 574

  Fly   169 DFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGF 233
            ...|:|:.||:|||..|||||:|::|:|||....||.|||:|||||:.|.||||..|:|..:|||
Human   575 RNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGF 639

  Fly   234 PEGVVNVVPGF-GTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIIL 297
            |:||:|::||. |.||..|:.|.|:.|:.|||||.:||.|..:...:|||:|:||||||||.||.
Human   640 PKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIF 704

  Fly   298 SDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGP 362
            :|.::|.||......:|||.|:.|.|..|.|||:.|:||||.|..|..||..:|:|.|.:|:.||
Human   705 NDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGP 769

  Fly   363 QVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQL 427
            |.::..:||:|...:||.|:||.||.|| |....||:|::||||.||:|.|.:|:||.|||:..:
Human   770 QNHKAHLEKLLQYCETGVKEGATLVYGG-RQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVI 833

  Fly   428 IRFKK--LDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKM 490
            .:|:.  :|.|::|||::|||||:.|||:|::||.|:...|.||||::||||.....|||||.|.
Human   834 SKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQ 898

  Fly   491 SGHGRENGEYALSNYTEVKSVIVK 514
            ||.|::.||.||:.|.:.|:|.::
Human   899 SGFGKDLGEEALNEYLKTKTVTLE 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AldhNP_609285.1 ALDH_F1AB_F2_RALDH1 34..514 CDD:143459 232/477 (49%)
ALDH1L2NP_001029345.2 Hydrolase domain. /evidence=ECO:0000250|UniProtKB:P28037 23..331
FMT_core_FDH_N 23..225 CDD:187716
FDH_Hydrolase_C 228..327 CDD:187731
PP-binding 346..>390 CDD:425746
Aldehyde dehydrogenase domain. /evidence=ECO:0000250|UniProtKB:P28037 438..923 232/479 (48%)
ALDH_F1L_FTFDH 439..923 CDD:143458 232/479 (48%)
Blue background indicates that the domain is not in the aligned region.

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