DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALDH1L2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001029345.2	Gene:	ALDH1L2 / 160428	HGNCID:	26777	Length:	923	Species:	Homo sapiens

Alignment Length:	479	Identity:	232/479 - (48%)
Similarity:	328/479 - (68%)	Gaps:	9/479 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRL 107
            |||.::..:..||.::|||||....|.::..|...|:|.||.||::||:.|. |.||:|.|||||
Human   446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMNARERGRL 509

  Fly   108 LYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD----G 168
            :||||||:|.:|..||::|.||:|..|:::....:..:::..||||||.||..|.|||::    .
Human   510 MYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPN 574

  Fly   169 DFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGF 233
            ...|:|:.||:|||..|||||:|::|:|||....||.|||:|||||:.|.||||..|:|..:|||
Human   575 RNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGF 639

  Fly   234 PEGVVNVVPGF-GTAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIIL 297
            |:||:|::||. |.||..|:.|.|:.|:.|||||.:||.|..:...:|||:|:||||||||.||.
Human   640 PKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIF 704

  Fly   298 SDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGP 362
            :|.::|.||......:|||.|:.|.|..|.|||:.|:||||.|..|..||..:|:|.|.:|:.||
Human   705 NDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGP 769

  Fly   363 QVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQL 427
            |.::..:||:|...:||.|:||.||.|| |....||:|::||||.||:|.|.:|:||.|||:..:
Human   770 QNHKAHLEKLLQYCETGVKEGATLVYGG-RQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVI 833

  Fly   428 IRFKK--LDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKM 490
            .:|:.  :|.|::|||::|||||:.|||:|::||.|:...|.||||::||||.....|||||.|.
Human   834 SKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQ 898

  Fly   491 SGHGRENGEYALSNYTEVKSVIVK 514
            ||.|::.||.||:.|.:.|:|.::
Human   899 SGFGKDLGEEALNEYLKTKTVTLE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	231/475 (49%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	232/477 (49%)
ALDH1L2	NP_001029345.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:278949
		Aldehyde dehydrogenase	438..923		232/479 (48%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	232/479 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820