DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and AgaP_AGAP009591

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_318614.3	Gene:	AgaP_AGAP009591 / 1278957	VectorBaseID:	AGAP009591	Length:	923	Species:	Anopheles gambiae

Alignment Length:	485	Identity:	217/485 - (44%)
Similarity:	310/485 - (63%)	Gaps:	9/485 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDA 101
            ::.|.:|||..:..::..|....:|||..:||.::..|.|.|:|.|||||..||:  ..|..:.|
Mosquito   440 VVPTQLFINGRFVDAEGAKTIPIVNPTNEKVICDVANASKADVDDAVQAADEAFR--GVWTSVSA 502

  Fly   102 SERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPM 166
            .|||:|:||||:|||:.:..||::|::|:|..|:::....:..:|...||:||||||..|.|||:
Mosquito   503 RERGQLMYRLAELMEQHREELATIESIDSGAVYTLALKTHVGMSIDAWRYYAGWADKIEGSTIPV 567

  Fly   167 D----GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQL 227
            .    ....|:|:.||:|||..|.|||:|::|::||:...:|.|||:|:|||:...||||..|:|
Mosquito   568 SPARPNRVLTFTKKEPIGVCALITPWNYPLMMLSWKMAACIAAGNTVVIKPAQVCPLTALKFAEL 632

  Fly   228 VKEAGFPEGVVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGK 291
            ...||||.||:|||.|.|: ||.|||:|..|.|:.|||||.:||.|..:...:|:|:.::|||||
Mosquito   633 TVRAGFPPGVINVVTGTGSLAGQALADHPAVRKLGFTGSTPIGKRIMASCAESNIKKCSMELGGK 697

  Fly   292 SPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDL 356
            ||.:|.:|.|::.||......:|||.|:.|.|..|.||||:|:||||.:.....|...:|:|.|.
Mosquito   698 SPLVIFADCDLEKAVRLGMSSVFFNKGENCIAAGRLFVEDRIHDEFVRKVIRGIKTMKIGDPLDR 762

  Fly   357 NTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTIAREEIF 421
            .|..|||.:...:||:......|.|:||||:.||.|...:.|.|.:||||.||:|.|.|||||.|
Mosquito   763 ATAHGPQNHRVHLEKLQEYCAIGVKEGAKLLYGGKRVPKMEGLFFEPTVFTDVEDHMYIAREESF 827

  Fly   422 GPVQQLIRF--KKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAP 484
            ||:..:.:|  ...|.::.|||::|||||:.|||:|:.||......:.||||:|||||.....||
Mosquito   828 GPIMVISKFHASDFDALVARANSTEYGLASGVFTQDIAKALRFAERVEAGTVFVNTYNKTDVAAP 892

  Fly   485 FGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            |||:|.||.|::.|:.||:.|.:.|.|.|:
Mosquito   893 FGGFKQSGFGKDLGKEALNEYLKTKCVTVE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	215/481 (45%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	216/483 (45%)
AgaP_AGAP009591	XP_318614.3	Fmt	12..321	CDD:223301
		FMT_core	12..213	CDD:294280
		FMT_C_like	219..322	CDD:301347
		PP-binding	346..407	CDD:278949
		ALDH-SF	439..923	CDD:299846	217/485 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820