DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and AgaP_AGAP003165

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_312856.4	Gene:	AgaP_AGAP003165 / 1273834	VectorBaseID:	AGAP003165	Length:	488	Species:	Anopheles gambiae

Alignment Length:	486	Identity:	179/486 - (36%)
Similarity:	271/486 - (55%)	Gaps:	36/486 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSP-WRRMDASERGR 106
            ::|..|..::||..|:..||....|:..:....::|:.:|:.||.:||.  .| |....|.||..
Mosquito    12 YVNGSWIGARSGATFDVQNPANGAVLGAVPDMARDDVQLAIDAAYDAFY--EPRWHNSTAKERAA 74

  Fly   107 LLYRLADLMERDQVYLASLETLDNGKP---------YSMSYNVDLPTAIKNLRYFAGWADKNHGK 162
            ||.....|||:::..:||:.|.::|||         |..|:          :.:||..|.:.:|:
Mosquito    75 LLKNWHALMEKNRQEIASIMTAESGKPLVESLGEVAYGNSF----------VEWFAEEARRIYGE 129

  Fly   163 TI--PMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIA 225
            .:  |:.......||: ||||.|.|.|||||..|:..|...|:|.|.|:|:||||.|.||||.:|
Mosquito   130 IVPSPVANRQIMMTRN-PVGVAGLITPWNFPHAMITRKAAAAIAAGCTVVIKPAEDTPLTALALA 193

  Fly   226 QLVKEAGFPEGVVNVVPGFGTAGAALAN-HCDVDKVA---FTGSTDVGKLI--QLASGNTNLKRV 284
            :|.:|||||:||:||:....|..|.:.. .|..||||   |||||:||||:  |.|.|   :||:
Mosquito   194 RLAEEAGFPKGVINVITSSRTHAAEIGQLLCGSDKVAAISFTGSTEVGKLLYRQCADG---VKRI 255

  Fly   285 TLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRT 349
            .|||||.:|.|:....||:.|:..|....|.|.||.|.:.:|..::|:::||||.:..||.:|..
Mosquito   256 GLELGGNAPFIVFKSADMEKALTGAMNSKFRNCGQTCISANRFLIQDEVHDEFVAKLIERIRKLA 320

  Fly   350 VGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGG-SRPEGLPGYFVQPTVFADVQDDM 413
            :|:......:.||.:|:.|::|:...::..|.:|||:..|| :.||..|.|: :|||..|::|:|
Mosquito   321 IGDGSRDGVQIGPLINQAQLKKVDQFVQDAKDKGAKVHTGGKTLPELGPLYY-EPTVVTDLRDNM 384

  Fly   414 TIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNV 478
            .:..||:||||..::|||...|.:..||.:..|||...|:.||::...:...|..|.:.:|...:
Mosquito   385 LLYNEEVFGPVVSVVRFKTEAEALAIANGTRRGLAGYFFSNDLNQVFRVARQLETGMIGINEGLI 449

  Fly   479 LAAQAPFGGYKMSGHGRENGEYALSNYTEVK 509
            .|.:|.|||.|.||.|||...:.:..|..:|
Mosquito   450 SATEAAFGGIKESGIGREGSRHGIDEYVYIK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	179/486 (37%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	179/486 (37%)
AgaP_AGAP003165	XP_312856.4	ALDH_F5_SSADH_GabD	28..483	CDD:143421	174/470 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810