DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and MMSA_ANOGA

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_312441.4	Gene:	MMSA_ANOGA / 1273463	VectorBaseID:	AGAP002499	Length:	521	Species:	Anopheles gambiae

Alignment Length:	521	Identity:	149/521 - (28%)
Similarity:	253/521 - (48%)	Gaps:	41/521 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ALLR---SQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAE 70
            ||||   ::.:|.         |.:..:|..:..|.:||:.::.:||:....:..:|.|.||:..
Mosquito     2 ALLRLVATECRNV---------LQRGYSTASVPTTKMFIDGKFVESKTNDWIDLHDPATNEVVTR 57

  Fly    71 IQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYS 135
            :....::::..||::::.|:|   .||:.....|.:::.:|..::..:...||...|.:.||..
Mosquito    58 VPKCTQDEMQTAVESSKKAYK---TWRQSSILSRQQVMLKLQHIIRNNMSELAKNITKEQGKTL- 118

  Fly   136 MSYNVDLPTAIKNLRYFAGWADKNHGKTIP-MDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKL 199
            :....|:...::.:.:.........|:|:| :..|..||:.|.|:||...|.|:|||.::..|..
Mosquito   119 IDAEGDVLRGLQVVEHCCSITSLQMGETVPNIAKDMDTYSYHLPLGVTAGIAPFNFPAMIPLWMF 183

  Fly   200 GPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTG 264
            ..|:..|||.::||:|:.....:.:.:::.|||.|.|||||:.|...|...:.::.|:..|:|.|
Mosquito   184 PVAITCGNTSIIKPSERVPGATMLLMEMLNEAGCPPGVVNVIHGAHDAVNFVCDNPDIRAVSFVG 248

  Fly   265 STDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGS---- 325
            |...||.|...:|. |.|||...:|.|:..:|::|.:.:..:.......|...||.|.|.|
Mosquito   249 SDQAGKYIYERAGR-NGKRVQCNMGAKNHGVIMADANKENTLNQLAGAAFGAAGQRCMALSTAVF 312

  Fly   326 ----RTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKL 386
                |.::.|.:         |||:|..|.......|:.||.::.:..::|..::::|.|:|||:
Mosquito   313 VGEARNWIPDLV---------ERARKLKVNAGHLPGTDLGPVISPQSKQRINELVESGAKEGAKI 368

  Fly   387 VAGGS--RPEGL-PGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLA 448
            |..|.  :.||. .|.||.||:.:||..:|....|||||||...:....:||.||..||:.||..
Mosquito   369 VLDGRNIKVEGFEKGNFVGPTIISDVTPNMKCYTEEIFGPVLVCLSVDTIDEAIELINNNPYGNG 433

  Fly   449 AAVFTKDLDKANYIVGGLRAGTVWVNT-YNVLAAQAPFGGYKMS--GHGRENGEYALSNYTEVKS 510
            .|:||.:...|...|..:..|.|.||. ..|......|.|.:.|  |.....|:..:..||:.|:
Mosquito   434 TAIFTTNGATARKFVNDIDVGQVGVNVPIPVPLPMFSFTGSRGSFLGDCHFYGKQGIKFYTQTKT 498

  Fly   511 V 511
            |
Mosquito   499 V 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	149/521 (29%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	143/493 (29%)
MMSA_ANOGA	XP_312441.4	ALDH_F6_MMSDH	27..503	CDD:143404	142/487 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910