DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_033786.1	Gene:	Aldh2 / 11669	MGIID:	99600	Length:	519	Species:	Mus musculus

Alignment Length:	521	Identity:	359/521 - (68%)
Similarity:	426/521 - (81%)	Gaps:	3/521 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTGALLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTA 65
            |||...|......:.....:|.|. |::|.|...|::....:|||||||.:.|.|.|.|:||:|.
Mouse     1 MLRAALTTVRRGPRLSRLLSAAAT-SAVPAPNHQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTG 64

  Fly    66 EVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDN 130
            |||.::...:|||:|.||:|||.||:|||||||||||:|||||||||||:|||:.|||:||||||
Mouse    65 EVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDN 129

  Fly   131 GKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMM 195
            ||||.:||.|||...:|.|||:||||||.||||||:|||||:|||||||||||||||||||:||.
Mouse   130 GKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQ 194

  Fly   196 AWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDK 259
            ||||||||||||.:|:|.||||.|||||:|.|:||||||.||||:||||| |||||:|:|..|||
Mouse   195 AWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEGVDK 259

  Fly   260 VAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAG 324
            |||||||:||.|||:|:|::|||||||||||||||||:||.|||:|||.|||.||||.|||||||
Mouse   260 VAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAG 324

  Fly   325 SRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG 389
            |||||::.:||||||||..|||.|.||||||..|||||||:|.|.:||||.||:|:::||||:.|
Mouse   325 SRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCG 389

  Fly   390 GSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTK 454
            |..... .|||:|||||.||:|.||||:|||||||.|:::||.::||:.|||:|:||||||||||
Mouse   390 GGAAAD-RGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANDSKYGLAAAVFTK 453

  Fly   455 DLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            |||||||:...|:|||||:|.|:|..||:|||||||||.|||.|||.|..|||||:|.|||.|||
Mouse   454 DLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKN 518

  Fly   520 S 520
            |
Mouse   519 S 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	347/503 (69%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	343/480 (71%)
Aldh2	NP_033786.1	PLN02466	3..518	CDD:215259	354/516 (69%)
Aldh2	NP_033786.1	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	343/480 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850246
Domainoid	1	1.000	699	1.000	Domainoid score	I127
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55480
Inparanoid	1	1.050	733	1.000	Inparanoid score	I604
Isobase	1	0.950	-	0	Normalized mean entropy	S334
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm43704
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	LDO	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750