Protein Alignment Aldh and Aldh1a1

DIOPT Version :9

• Sequence 1: NP_001260290.1
• Gene: Aldh / 34256
• FlyBaseID: FBgn0012036
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001348432.1
• Gene: Aldh1a1 / 11668
• MGIID: 1353450
• Length: 501
• Species: Mus musculus
• Alignment Length: 495
• Identity: 314/495 - (63%)
• Similarity: 396/495 - (80%)
• Gaps: 2/495 - (0%)

  Fly    27 SLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFK 91
            ::|.|.....|.:|.:|||||||.|.|||.|..:||.|.|||..::..||.|:|.||:|||.||:
Mouse     8 AVPAPLADLKIQHTKIFINNEWHNSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQ 72

  Fly    92 LGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWA 156
            :|||||.||||||||||.:||||||||::.||::|.|:.||.::.:|..||...||.|:|.||||
Mouse    73 IGSPWRTMDASERGRLLNKLADLMERDRLLLATMEALNGGKVFANAYLSDLGGCIKALKYCAGWA 137

  Fly   157 DKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTA 221
            ||.||:|||.|||.|||||.||:||||||||||||:||..||:||||:.|||:|:||||||.|||
Mouse   138 DKIHGQTIPSDGDIFTYTRREPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPLTA 202

  Fly   222 LYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVT 285
            |::|.|:||||||.||||:|||:| |||||:::|.|||||||||||.|||||:.|:|.:||||||
Mouse   203 LHLASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVT 267

  Fly   286 LELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTV 350
            ||||||||.|:.:|.|:|.|||.||.|:|::.||||.|.||.|||:.:|||||:||.|||||..:
Mouse   268 LELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYVL 332

  Fly   351 GNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFADVQDDMTI 415
            |||......||||:::||.:|||.:|::|||:||||..||.| .|..|:|||||||::|.|:|.|
Mouse   333 GNPLTPGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGR-WGNKGFFVQPTVFSNVTDEMRI 396

  Fly   416 AREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLA 480
            |:|||||||||:::||.:|:||:||||:.|||||.:||||||||..:...|:||.||||.|.:|:
Mouse   397 AKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSALQAGVVWVNCYMMLS 461

  Fly   481 AQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            ||.||||:||||:|||.||:.|..|||:|:|.:|::||||
Mouse   462 AQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	308/485 (64%)
		ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	307/480 (64%)
Aldh1a1	NP_001348432.1	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	307/480 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2025
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.960