DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh1a2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_446348.2	Gene:	Aldh1a2 / 116676	RGDID:	620250	Length:	518	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	323/503 - (64%)
Similarity:	407/503 - (80%)	Gaps:	2/503 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAV 83
            ||.:|:...||.|....:|.||.:||||||..|:||::|...||.|.|.:.|:|.|||.|||.||
  Rat    17 AALMASLQLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAV 81

  Fly    84 QAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKN 148
            ||||.||.|||.|||||||||||||.:||||:|||:..||::|:|:.|||:..::.:||...||.
  Rat    82 QAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKT 146

  Fly   149 LRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKP 213
            |||:||||||.||.|||:|||:||:|||||:||||||||||||:||..||:.|||..|||:|:||
  Rat   147 LRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKP 211

  Fly   214 AEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTGSTDVGKLIQLASG 277
            ||||.|:|||:..|:||||||.||||::||:| |||||:|:|..:||:||||||:||||||.|:|
  Rat   212 AEQTPLSALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 276

  Fly   278 NTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSA 342
            .:|||||||||||||||||.:|.|:|||||.||.|:|||.||||.||||.|||:.||:|||:||.
  Rat   277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVKRSV 341

  Fly   343 ERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEGLPGYFVQPTVFA 407
            ||||:|.||:|||..||||||::::|..|||.:|::|..:||||..|| :..|..|:|::||||:
  Rat   342 ERAKRRIVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-KGLGRKGFFIEPTVFS 405

  Fly   408 DVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVW 472
            :|.|||.||:||||||||:::|||.:||||||||||::||.|||||.|::||..:...::|||||
  Rat   406 NVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALMVSSAMQAGTVW 470

  Fly   473 VNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            :|.||.|.||:||||:||||:|||.||:.|..|:|||:|.||:.||||
  Rat   471 INCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	316/493 (64%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	311/480 (65%)
Aldh1a2	NP_446348.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	311/480 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930