DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and ALDH1L1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens

Alignment Length:	478	Identity:	238/478 - (49%)
Similarity:	323/478 - (67%)	Gaps:	11/478 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGR 106
            :||..|:..::..|..||||||...||.::..|...|:|.||.||::||:.|. |.::.|.:|||
Human   434 LFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKISARDRGR 497

  Fly   107 LLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMD---- 167
            |:||||||||:.|..||::|.||.|..|:::....:..:|:..||||||.||..|.|||::
Human   498 LMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARP 562

  Fly   168 GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAG 232
            ....|.||.|||||||.|||||:|::|::||....||.|||:|:|||:.|.||||..|:|..:||
Human   563 NRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAG 627

  Fly   233 FPEGVVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNII 296
            .|:|||||:||.|: .|..|::|.||.|:.|||||:|||.|..:...:|:|:|:||||||||.||
Human   628 IPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLII 692

  Fly   297 LSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQG 361
            .:|.|::.||:.....:|||.|:.|.|..|.||||.|:||||.|..|..:|..||||.|.:|:.|
Human   693 FADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHG 757

  Fly   362 PQVNEEQMEKILGMIKTGKKQGAKLVAGGSR-PEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQ 425
            ||.:...:.|::...:.|.|:||.||.||:: |.  ||:|.:||||.||:|.|.||:||.||||.
Human   758 PQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR--PGFFFEPTVFTDVEDHMFIAKEESFGPVM 820

  Fly   426 QLIRFK--KLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGY 488
            .:.||.  .||.|:.|||.:|:|||:.|||:|::||.|:...|:||||:|||||.....|||||:
Human   821 IISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGF 885

  Fly   489 KMSGHGRENGEYALSNYTEVKSV 511
            |.||.|::.||.||:.|..||:|
Human   886 KQSGFGKDLGEAALNEYLRVKTV 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	238/478 (50%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	238/478 (50%)
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949
		ALDH_F1L_FTFDH	427..912	CDD:143458	238/478 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820