DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001343341.1	Gene:	Aldh1l1 / 107747	MGIID:	1340024	Length:	902	Species:	Mus musculus

Alignment Length:	498	Identity:	236/498 - (47%)
Similarity:	330/498 - (66%)	Gaps:	12/498 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAA 86
            |.||......:.|..:.|. :||..|:..::..|.:.|||||...||.::..|...|:|.||.||
Mouse   405 VINYVEKAVKKLTLQMPYQ-LFIGGEFVDAEGAKTYSTINPTDGSVICQVSLAQVSDVDKAVAAA 468

  Fly    87 RNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRY 151
            :.||:.|. |.:::|.:|||||||||||||:.|..||::|.||.|..|:::....:..:|:..||
Mouse   469 KEAFENGL-WGKINARDRGRLLYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRY 532

  Fly   152 FAGWADKNHGKTIPMD----GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLK 212
            ||||.||..|.|||::    ....|.|:.|||||||.:||||:|::|::||....||.|||:|:|
Mouse   533 FAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIK 597

  Fly   213 PAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGT-AGAALANHCDVDKVAFTGSTDVGKLIQLAS 276
            ||:.|.||||..|:|..:||.|:||||::||.|: .|..|::|.||.|:.|||||:|||.|..:.
Mouse   598 PAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSC 662

  Fly   277 GNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERS 341
            ..:|:|:|:||||||||.||.:|.|::.||:.....:|||.|:.|.|..|.||||.|:|:||::.
Mouse   663 ALSNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDQFVQKV 727

  Fly   342 AERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR-PEGLPGYFVQPTV 405
            .|...|..:|||.|.:|..|||.:|..:.|::...:.|.|:||.||.||:: |.  ||:|.||||
Mouse   728 VEEVGKMKIGNPLDRDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPR--PGFFFQPTV 790

  Fly   406 FADVQDDMTIAREEIFGPVQQLIRFK--KLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRA 468
            |.||:|.|.||:||.|||:..:.||.  .:|.|:.|||.:|:|||:.|||:|::||.|:...|:|
Mouse   791 FTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQA 855

  Fly   469 GTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSV 511
            |||:|||||.....|||||:|.||.|::.||.||:.|..:|:|
Mouse   856 GTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	236/498 (47%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	233/486 (48%)
Aldh1l1	NP_001343341.1	FMT_core_FDH_N	1..203	CDD:187716
		GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		FDH_Hydrolase_C	206..306	CDD:187731
		PP-binding	325..391	CDD:306928
		ALDH_F1L_FTFDH	417..902	CDD:143458	233/486 (48%)
		Aldehyde dehydrogenase	417..902		233/486 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820