DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and wu:fb14d09

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_009296559.2	Gene:	wu:fb14d09 / 100536795	ZFINID:	ZDB-GENE-030131-8536	Length:	516	Species:	Danio rerio

Alignment Length:	521	Identity:	358/521 - (68%)
Similarity:	425/521 - (81%)	Gaps:	6/521 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRVLKTGALLRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTA 65
            |||.:    ..|:..:.|..:...:|::|.|...||:.|..:|||||||.:.|.|.|.||||.|.
Zfish     1 MLRTV----FSRTFPQVFRISSCQHSTIPAPNVQPDVHYNKIFINNEWHDAVSKKTFPTINPATG 61

  Fly    66 EVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDN 130
            |:|..:...||.|:|.||:|||:||||||||||||||:||.||.||||.:|||..|||.||||||
Zfish    62 EIICHVAEGDKADVDKAVKAARDAFKLGSPWRRMDASQRGLLLSRLADCIERDAAYLAELETLDN 126

  Fly   131 GKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMM 195
            ||||::|::||:|..:|.:||:||||||..|||||:||::|.||||||:||||||||||||:||.
Zfish   127 GKPYAVSFSVDVPMVVKCMRYYAGWADKWEGKTIPIDGNYFCYTRHEPIGVCGQIIPWNFPLLMQ 191

  Fly   196 AWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDK 259
            |||||||||||||:|:|.||||.|||||||.|:||.|||.||||:||||| |||||:|:|.||||
Zfish   192 AWKLGPALATGNTVVMKVAEQTPLTALYIASLIKEVGFPAGVVNIVPGFGPTAGAAIASHMDVDK 256

  Fly   260 VAFTGSTDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAG 324
            ||||||||||.|||.||..:|||:||||||||||||||||.:|:.|||.:|..||||.|||||||
Zfish   257 VAFTGSTDVGHLIQRASSASNLKKVTLELGGKSPNIILSDANMEEAVEQSHIALFFNQGQCCCAG 321

  Fly   325 SRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAG 389
            :||||::.|||||||||.||||.|.||:||||||||||||||:|.:|:||.|.:||::||||:.|
Zfish   322 TRTFVQESIYDEFVERSVERAKNRIVGDPFDLNTEQGPQVNEDQFKKVLGYISSGKREGAKLMCG 386

  Fly   390 GSRPEGLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTK 454
            |: |....|||:|||||.||:||||||||||||||.|:::||.|:|||||||:|:||||.||||:
Zfish   387 GA-PAAERGYFIQPTVFGDVKDDMTIAREEIFGPVMQILKFKSLEEVIERANDSKYGLAGAVFTQ 450

  Fly   455 DLDKANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKN 519
            |:||||||..||||||||:|.|||...||||||||.||.|||.|||.|.||||||:|.:||.:||
Zfish   451 DIDKANYISHGLRAGTVWINCYNVFGVQAPFGGYKASGIGREMGEYGLENYTEVKTVTIKVPEKN 515

  Fly   520 S 520
            |
Zfish   516 S 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	349/503 (69%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	345/480 (72%)
wu:fb14d09	XP_009296559.2	ALDH_F1AB_F2_RALDH1	30..510	CDD:143459	345/480 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860