DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh1b1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_004910950.1	Gene:	aldh1b1 / 100498540	XenbaseID:	XB-GENE-1013740	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	516	Identity:	332/516 - (64%)
Similarity:	419/516 - (81%)	Gaps:	8/516 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RSQAKNFAAAV----ANYSS--LPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAE 70
            ||.:.::...:    |.:|:  :|:|.:.|::.||.:||||||..:.||:.|.|::|.|.|||..
Frog     3 RSFSHHYIGTIWQMGARFSTAIIPKPLSNPEVFYTKLFINNEWRDAVSGRRFPTVDPCTGEVITH 67

  Fly    71 IQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYS 135
            :..|||.|||.||:|||.|||.|||||.||||:||:||:|||||:|||::|||||||:|||||::
Frog    68 VAEADKADIDAAVKAAREAFKQGSPWRSMDASQRGQLLHRLADLIERDKIYLASLETMDNGKPFA 132

  Fly   136 MSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLG 200
            .|:.:||.|.:|..||:||:|||.||||||:||::|.|||||||||||||||||||::|..||||
Frog   133 DSFAIDLSTVVKVYRYYAGFADKVHGKTIPLDGNYFCYTRHEPVGVCGQIIPWNFPLVMQGWKLG 197

  Fly   201 PALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFG-TAGAALANHCDVDKVAFTG 264
            ||||||||:|:|.||||.|:|||||.|:||||:|.||||::.||| |||||||.|.||||:||||
Frog   198 PALATGNTVVMKVAEQTPLSALYIASLIKEAGYPPGVVNILTGFGPTAGAALAQHMDVDKIAFTG 262

  Fly   265 STDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFV 329
            ||:||:|||.|:|:|||||||||||||||.|:::|.|::.|||..|..|||||||||.|||||||
Frog   263 STEVGRLIQKAAGSTNLKRVTLELGGKSPCIVMADADLEQAVEQCHEALFFNMGQCCAAGSRTFV 327

  Fly   330 EDKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPE 394
            |:.:||||:||:.|:||.|.|||||||:|:.|||:|:||.:||||.||:||.:||||:.||.| .
Frog   328 EENVYDEFLERTVEKAKLRKVGNPFDLDTKHGPQINKEQFDKILGYIKSGKTEGAKLMCGGER-Y 391

  Fly   395 GLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKA 459
            |..|:|::|||||:|||:|.|||||||||||.:.:||.:.||||||||:.|||||.:||:|||||
Frog   392 GDKGFFIKPTVFANVQDNMKIAREEIFGPVQPVFKFKSIKEVIERANNTSYGLAAGIFTRDLDKA 456

  Fly   460 NYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            ..:...||||||||||||::..|.||||:|.||:|||.||..|..|||||:|.:|::.|.|
Frog   457 MLLTQALRAGTVWVNTYNIVTCQTPFGGFKESGNGRELGEDGLKAYTEVKTVTMKISHKKS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	328/506 (65%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	323/480 (67%)
aldh1b1	XP_004910950.1	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	323/480 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	687	1.000	Domainoid score	I133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53964
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	1	1.000	-	-		otm48874
Panther	1	1.100	-	-	O	PTHR11699
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.030