DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh and aldh1l2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_002938116.1	Gene:	aldh1l2 / 100127737	XenbaseID:	XB-GENE-5820495	Length:	922	Species:	Xenopus tropicalis

Alignment Length:	511	Identity:	239/511 - (46%)
Similarity:	333/511 - (65%)	Gaps:	12/511 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRSQAKNFAAAVANYSSLPQPQTTPDILYTGVFINNEWHKSKSGKIFETINPTTAEVIAEIQCAD 75
            ||.:.|.  ..|.:|:||.....|..:.|. .|||.::..:.:||.::|||||...||.::....
Frog   416 LRGEDKE--ELVIDYASLNVNNMTVKMPYQ-CFINGQFADADNGKTYDTINPTDGSVICKVAYCS 477

  Fly    76 KEDIDIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNV 140
            ..|:|.||.||::||:.|. |.:|:|.:|||:|||||||||..|..||::|.:|:|..|:::...
Frog   478 VADVDKAVAAAKDAFENGE-WGKMNARDRGRILYRLADLMEEHQEELATIEAIDSGAVYTLALKT 541

  Fly   141 DLPTAIKNLRYFAGWADKNHGKTIPMD----GDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGP 201
            .:..:::..||||||.||..|.|||::    ....|:|:.||:|||..:||||:|::|:|||...
Frog   542 HVGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIVIPWNYPLMMLAWKSAA 606

  Fly   202 ALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGF-GTAGAALANHCDVDKVAFTGS 265
            .||.|||:|||||:.|.||||..|:|..:||.|:||:|::||. |..|..|:.|.|:.|:.||||
Frog   607 CLAAGNTLVLKPAQVTPLTALKFAELAVKAGVPKGVINILPGSGGLVGQRLSEHPDIRKLGFTGS 671

  Fly   266 TDVGKLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVE 330
            |.:||.|..:...:|||:|:||||||||.||.:|.|:|.||......::||.|:.|.|..|.|||
Frog   672 TPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCDLDKAVRMGMGAVYFNKGENCIAAGRLFVE 736

  Fly   331 DKIYDEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRPEG 395
            :.|:||||.|..|..||..:|:|.|.:|:.|||.:...:||:|...:.|.|:||.||.|| |...
Frog   737 ESIHDEFVTRVVEEIKKMRIGDPLDRSTDHGPQNHRAHLEKLLEYCEIGVKEGATLVYGG-RKVP 800

  Fly   396 LPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFK--KLDEVIERANNSEYGLAAAVFTKDLDK 458
            .||:|::||||.||:|.|.:|.||.|||:..:.:||  .:|.|:.||||:|||||:.|||||:.|
Frog   801 RPGFFMEPTVFTDVEDHMYLAEEESFGPIMVISKFKDGDIDGVLRRANNTEYGLASGVFTKDISK 865

  Fly   459 ANYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVK 514
            |.|:...|.||||::||||.....|||||:|.||.|::.||.||..|...|:|.|:
Frog   866 AMYVSEKLDAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEEALHEYLRTKAVTVE 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	237/507 (47%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	231/486 (48%)
aldh1l2	XP_002938116.1	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..412	CDD:376348
		ALDH_F1L_FTFDH	437..922	CDD:143458	232/488 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010