DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh9a1a.2

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_021333836.1	Gene:	aldh9a1a.2 / 100006238	ZFINID:	ZDB-GENE-081104-507	Length:	512	Species:	Danio rerio

Alignment Length:	516	Identity:	192/516 - (37%)
Similarity:	304/516 - (58%)	Gaps:	35/516 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SLPQPQTTPDILYTGVFINNE----W--------HKSKSGKIFETINPTTAEVIAEIQCADKEDI 79
            |||:.|:    :.||..:..|    |        :...|..::|   |.|..|:.::....:|::
Zfish     8 SLPEFQS----VSTGTLVVKEPLNFWAGARVKPSNTKNSEPVYE---PATGRVLCDMIPCGEEEV 65

  Fly    80 DIAVQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPT 144
            |.|:::|.:|:   ..|.::...||.|::...|.::...:..:|..:..:||...:.: .||:..
Zfish    66 DQAIKSAHSAY---LKWSQLSGMERSRIMLEAARIIRERRDAIAKTDVANNGTSITEA-KVDIDL 126

  Fly   145 AIKNLRYFAGWADKNHGKT----IPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALAT 205
            |.|.:.|:||.|....|.:    |.:.|..|.|||.||:|||..|..||:|..:.|||..||:|.
Zfish   127 AWKCIEYYAGIAPTLSGSSRHSHIQLPGGSFAYTRREPLGVCVGIGAWNYPFQIAAWKSAPAIAC 191

  Fly   206 GNTIVLKPAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVG- 269
            ||.:|.||:..|.:||:.:|::.||||.|:|:.|||.|....|:.|.:|..|.||:.||....|
Zfish   192 GNAMVFKPSPMTPVTAVMLAEIYKEAGVPDGLFNVVQGGPETGSLLCHHPMVAKVSLTGGVPTGK 256

  Fly   270 KLIQLASGNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIY 334
            |::::|:  ..:|:||||||||||.||.:|.:::.|::.|....|...|:.||.|:|.||:.:|.
Zfish   257 KVLEMAA--KGVKQVTLELGGKSPLIIFNDCELENAIKGALMANFLTKGEVCCNGTRVFVQREIM 319

  Fly   335 DEFVERSAERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR-----PE 394
            .:|:|...:|.|..:||:|....|..|..:::..|||:||.||..|:||||::.||.:     |:
Zfish   320 PKFLEEVVKRTKAISVGDPLCEGTRMGALISKPHMEKVLGFIKQAKEQGAKVLCGGEQFVPNDPK 384

  Fly   395 GLPGYFVQPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKA 459
            ...||||.|.|..:.:||||..:|||||||..::.|...:||::||||:.:|||:.|||:|:.:|
Zfish   385 LKDGYFVSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDIARA 449

  Fly   460 NYIVGGLRAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            :.::..|:||..::|.|||...:.|||||||||.|:|||...:..|:::|:|:|::....|
Zfish   450 HRVIANLQAGMCYINNYNVCPVEVPFGGYKMSGFGKENGALTIEYYSQLKTVVVEMGDVES 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	189/506 (37%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	186/501 (37%)
aldh9a1a.2	XP_021333836.1	ALDH_F9_TMBADH	45..506	CDD:143409	182/469 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810