DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldh9a1a.1

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_958879.1	Gene:	aldh9a1a.1 / 100005587	ZFINID:	ZDB-GENE-030131-1257	Length:	508	Species:	Danio rerio

Alignment Length:	509	Identity:	199/509 - (39%)
Similarity:	306/509 - (60%)	Gaps:	25/509 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SLPQPQTTPDILYTGVFINNE----WH----KSKSGKIFETI-NPTTAEVIAEIQCADKEDIDIA 82
            |||:.|:    :.||..:..|    |.    |.:..|..|.: .|.|..|:.::....:|::|.|
Zfish     8 SLPEFQS----VSTGTLVVKEPLNFWGGARVKPRDTKNSEPVYEPATGRVLCDMIPCGEEEVDQA 68

  Fly    83 VQAARNAFKLGSPWRRMDASERGRLLYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIK 147
            :::|.:|:   ..|.::...||.|::...|.::...:..:|..|..:|||..:.: .||:..|.:
Zfish    69 IKSAHSAY---LKWSQLSGMERSRIMLEAARIIRERRNAIAKAEVANNGKSITEA-EVDIDVAWQ 129

  Fly   148 NLRYFAGWADKNHGKTIPMDGDFFTYTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLK 212
            .:.|:||.|....|:.|.:.|..|.|||.||:|||..|..||:|..:.|||..||||.||.:|.|
Zfish   130 CIEYYAGIAPTLSGQHIQLPGGSFAYTRREPLGVCVGIGAWNYPFQIAAWKSAPALACGNAMVFK 194

  Fly   213 PAEQTSLTALYIAQLVKEAGFPEGVVNVVPGFGTAGAALANHCDVDKVAFTGSTDVG-KLIQLAS 276
            |:..|.:||:.:|::.||||.|:|:.|||.|....|:.|.:|..|.||:||||...| |::::|:
Zfish   195 PSPMTPVTAVMLAEIYKEAGVPDGLFNVVQGGAETGSLLCHHPMVAKVSFTGSVPTGKKVMEMAA 259

  Fly   277 GNTNLKRVTLELGGKSPNIILSDTDMDYAVETAHFGLFFNMGQCCCAGSRTFVEDKIYDEFVERS 341
              .::|:||||||||||.||..|.:::.|::.|....|...|:.||.|:|.||:.:|..:|:|..
Zfish   260 --KSVKQVTLELGGKSPLIIFKDCELENAIKGALMANFLTQGEVCCNGTRVFVQREIMPKFLEEV 322

  Fly   342 AERAKKRTVGNPFDLNTEQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSR-----PEGLPGYFV 401
            .:|.|..:||:|....|..|..:::..|||:||.||..|:||.|::.||.|     |:...||||
Zfish   323 VKRTKAISVGDPLCEGTRMGALISKPHMEKVLGFIKQAKEQGGKVLCGGERFVPNDPKLKDGYFV 387

  Fly   402 QPTVFADVQDDMTIAREEIFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGL 466
            .|.|..:.:||||..:|||||||..::.|...:||::||||:.:|||:.|||:|:.:|:.:...|
Zfish   388 SPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDIARAHRVAANL 452

  Fly   467 RAGTVWVNTYNVLAAQAPFGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQKNS 520
            :|||.::|.|||...:.|||||||||.|||||...:..|:::|:|:|::....|
Zfish   453 QAGTCYINNYNVGPVEVPFGGYKMSGFGRENGTVTIEYYSQLKTVVVEMGDVES 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	196/499 (39%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	193/494 (39%)
aldh9a1a.1	NP_958879.1	ALDH_F9_TMBADH	45..502	CDD:143409	187/462 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810