DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat1 and SLC1A6

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001371598.1	Gene:	SLC1A6 / 6511	HGNCID:	10944	Length:	564	Species:	Homo sapiens

Alignment Length:	484	Identity:	212/484 - (43%)
Similarity:	303/484 - (62%)	Gaps:	51/484 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITS 78
            |::.|...:.||..|.:|..:.|.::  ..:.:.|:|.|.|||||:.:|||:.|::||:|||:.:
Human    52 FLRRNAFILLTVSAVVIGVSLAFALR--PYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVT 114

  Fly    79 AIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASK---VL 140
            .:..||...:.::..||..||.||||.||.:||.:||.:.||:|:|      |.:.:..:   :.
Human   115 GMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSK------EGLHREGRIETIP 173

  Fly   141 TPDTLMDLVRNMFTDNIIQSTMFQHRTEI-----------YEN-----TSISPAQPMEN------ 183
            |.|..|||:||||..|::::...|.:|:.           .||     .|:.|...:||
Human   174 TADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLE 238

  Fly   184 ---------WEFKSAQR--------EGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAM 231
                     .|..|.:.        .|.|.||||:|||..|..||.|:.||::|:|||.:|:||:
Human   239 NVTRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAI 303

  Fly   232 MTITSWVIWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRR 296
            |.:...:||.:|:|:.||||.||:|||.:|.....||.|.:||::|||||....:.:|:||.|.|
Human   304 MRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHR 368

  Fly   297 LPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAV 360
            .|:.:|..:.|.|.||.||.|||||:|:|.:|| :.:|:|.|:||||:|||||:||||||||||:
Human   369 NPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEAL 433

  Fly   361 AALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDW 425
            ||:||||......:.|.|..:||||||||:||||||||||||||:||.:|||..:|::|||||||
Human   434 AAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDW 498

  Fly   426 LLDRFRTTINVMCDALGTILVNHLSKNDL 454
            .|||.||..||:.|::|..::.|||:.:|
Human   499 FLDRLRTMTNVLGDSIGAAVIEHLSQREL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	206/471 (44%)
SLC1A6	NP_001371598.1	SDF	58..522	CDD:395299	206/471 (44%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	388..390		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	468..472		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I800
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21055
Inparanoid	1	1.050	400	1.000	Inparanoid score	I1941
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm41925
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880