DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and SLC1A5

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_005619.1	Gene:	SLC1A5 / 6510	HGNCID:	10943	Length:	541	Species:	Homo sapiens

Alignment Length:	468	Identity:	173/468 - (36%)
Similarity:	284/468 - (60%)	Gaps:	27/468 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MQENVLTMATVIGVFVGGLIGFIIKNSTGEWS--KREIMYISFPGEIFLRMLKCLIVPLLVSSIT 77
            ::.|:|.:.||:.|..|..:|..:..:.|..:  ...:....||||:.||:|:.:|:||:|.|:.
Human    49 LRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLI 113

  Fly    78 SAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKA-----S 137
            .....||.....::...|:.::.|||:.|..||:.|...|:||..:..:.....:...|     .
Human   114 GGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSK 178

  Fly   138 KVLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQ---PMENWEFKSAQREGSNVLGL 199
            :||  |:.:||.||:|..|:: |..|:..:..||..:|:..:   |:      ..:.||.|:|||
Human   179 EVL--DSFLDLARNIFPSNLV-SAAFRSYSTTYEERNITGTRVKVPV------GQEVEGMNILGL 234

  Fly   200 VMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMESIAATI 264
            |:|:::.|..:.::..:|:||..||.:.:||.|.:.||::|.:|:|:.||:|.||:|||.:....
Human   235 VVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLF 299

  Fly   265 QSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL 329
            ..||.|.:..::|..:||...:.:|:||.||:.|||::..:...|||||||.|||||:||.:||:
Human   300 ARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCV 364

  Fly   330 -DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAA 393
             :|.|:...::||::|:|||:||||.||::.|||:||||..:.|..|..|:.:.:||||:|:|||
Human   365 EENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAA 429

  Fly   394 GIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGT-ILVNHLSKNDLASV 457
            |||..|::|:.::|:.|.|....:|||:|||||:||..|.:||..||||. :|.|::.:.:..|
Human   430 GIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRS- 493

  Fly   458 DRLNAEPHELLEL 470
                .|| ||:::
Human   494 ----TEP-ELIQV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	167/440 (38%)
SLC1A5	NP_005619.1	SDF	106..482	CDD:395299	150/384 (39%)
SLC1A5	NP_005619.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.790