DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat1 and SLC1A4

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_003029.2	Gene:	SLC1A4 / 6509	HGNCID:	10942	Length:	532	Species:	Homo sapiens

Alignment Length:	465	Identity:	169/465 - (36%)
Similarity:	292/465 - (62%)	Gaps:	16/465 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITS 78
            |::...|.:.||.||..|..:|..::..:  .|:.::.|::||||:.||||:.:|:||:|.|:.|
Human    38 FLRRQALVLLTVSGVLAGAGLGAALRGLS--LSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVS 100

  Fly    79 AIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASKVLTP- 142
            ....||.|...::...|:.|:.:||:||..|.:.|...::||.||:.:::....::.:.....|
Human   101 GAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPK 165

  Fly   143 ---DTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQPMENWEFK-SAQREGSNVLGLVMFS 203
               |:.:||.||:|..|::.:....:.|:....|..|.:..:.:.:.. ..:.||.|:||||:|:
Human   166 ETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFA 230

  Fly   204 VILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMESIAATIQSLG 268
            ::||..:.::..:|:.|..||.:|:||.|.:.||::|..|:|:.||:.:||:||:.|...:.|||
Human   231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLG 295

  Fly   269 WYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNM 332
            .|....::|..:||...:.:|:|:.||:.|:|::..|....||||.|.|||||:|..:||: :|.
Human   296 KYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN 360

  Fly   333 GIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQ 397
            |:|.|::||::|:|||:||||.|:::.|||:||||...:..:.|.|..:.:||||:|:||||:|.
Human   361 GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPA 425

  Fly   398 AGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLS-------KNDLA 455
            .|::|:.::|:.:||...|:.||:||||::||..|.:||..||||..:::||:       :.:||
Human   426 GGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA 490

  Fly   456 SVDRLNAEPH 465
            .| ::.|.|:
Human   491 EV-KVEAIPN 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	161/434 (37%)
SLC1A4	NP_003029.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		SDF	72..477	CDD:306807	153/404 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..532		169/465 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I800
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.890