DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eaat1 and SLC1A4

DIOPT Version :10

Sequence 1:NP_001369123.1 Gene:Eaat1 / 34251 FlyBaseID:FBgn0026439 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_003029.2 Gene:SLC1A4 / 6509 HGNCID:10942 Length:532 Species:Homo sapiens


Alignment Length:465 Identity:169/465 - (36%)
Similarity:292/465 - (62%) Gaps:16/465 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 FMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITS 78
            |::...|.:.||.||..|..:|..::..:  .|:.::.|::||||:.||||:.:|:||:|.|:.|
Human    38 FLRRQALVLLTVSGVLAGAGLGAALRGLS--LSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVS 100

  Fly    79 AIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASKVLTP- 142
            ....||.|...::...|:.|:.:||:||..|.:.|...::||.||:.:::....::.:.....| 
Human   101 GAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPK 165

  Fly   143 ---DTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQPMENWEFK-SAQREGSNVLGLVMFS 203
               |:.:||.||:|..|::.:....:.|:....|..|.:..:.:.:.. ..:.||.|:||||:|:
Human   166 ETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFA 230

  Fly   204 VILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMESIAATIQSLG 268
            ::||..:.::..:|:.|..||.:|:||.|.:.||::|..|:|:.||:.:||:||:.|...:.|||
Human   231 LVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLG 295

  Fly   269 WYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNM 332
            .|....::|..:||...:.:|:|:.||:.|:|::..|....||||.|.|||||:|..:||: :|.
Human   296 KYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN 360

  Fly   333 GIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQ 397
            |:|.|::||::|:|||:||||.|:::.|||:||||...:..:.|.|..:.:||||:|:||||:|.
Human   361 GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPA 425

  Fly   398 AGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLS-------KNDLA 455
            .|::|:.::|:.:||...|:.||:||||::||..|.:||..||||..:::||:       :.:||
Human   426 GGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELA 490

  Fly   456 SVDRLNAEPH 465
            .| ::.|.|:
Human   491 EV-KVEAIPN 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Eaat1NP_001369123.1 GltP 20..448 CDD:440912 161/433 (37%)
SLC1A4NP_003029.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
GltP 72..471 CDD:440912 152/398 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..532 169/465 (36%)
Blue background indicates that the domain is not in the aligned region.

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