DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat1 and SLC1A1

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_011516309.1	Gene:	SLC1A1 / 6505	HGNCID:	10939	Length:	547	Species:	Homo sapiens

Alignment Length:	502	Identity:	218/502 - (43%)
Similarity:	310/502 - (61%)	Gaps:	49/502 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRPKQDGGKFKAFMQENVLTMATVIGVFVG----------------------GLIGFIIKNSTG 43
            |.:|.:.|.::|.|::.|.:.::||..|.:.                      |:...::.....
Human     1 MGKPARKGCEWKRFLKNNWVLLSTVAAVVLDCKPHGDPDHMSSTELSKVVVCTGITTGVLVREHS 65

  Fly    44 EWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVI 108
            ..|..|..|.:|||||.:||||.:|:||::||:.:.:..||.::|.||..||:.|||.||:.|||
Human    66 NLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVI 130

  Fly   109 LGICLVTTLRPGQGAKIVE-TQTESIDKASKVLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYE- 171
            |||.||.:::||...|:.| .:|.|..:.|   |.|.::||:||||.:|::|:...|::|:..|
Human   131 LGIVLVVSIKPGVTQKVGEIARTGSTPEVS---TVDAMLDLIRNMFPENLVQACFQQYKTKREEV 192

  Fly   172 -------------------NTSISPAQPMENWEFKSAQREGSNVLGLVMFSVILGTTIGRMREKG 217
                               .|:||..:..| ::......:|.|||||::|.::.|..||:|.|||
Human   193 KPPSDPEMNMTEESFTAVMTTAISKNKTKE-YKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKG 256

  Fly   218 QLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHG 282
            |:|.|||..||:|.|.|...::...|||:.||||.||||:|. ....:.||.|..||:.||.:|.
Human   257 QILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVED-WEIFRKLGLYMATVLTGLAIHS 320

  Fly   283 FGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPRVTRFVIPVG 346
            ...:.:|:|:..|:.|:|:...::|.|.||....|||||:|:|.:|. :|..:|.|:||||:|||
Human   321 IVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVG 385

  Fly   347 ATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVG 411
            ||||||||||||||||:||||..::....|.|:.:|||||:|||||||:|||||||||:||..||
Human   386 ATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVG 450

  Fly   412 LEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLSKNDLASVD 458
            |..:||:||||||||||||||.:||:.||.||.:|..|||.:|..:|
Human   451 LPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	207/472 (44%)
SLC1A1	XP_011516309.1	SDF	74..488	CDD:278787	201/418 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I800
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	400	1.000	Inparanoid score	I1941
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm41925
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	LDO	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880