DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and slc1a8b

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001177745.1	Gene:	slc1a8b / 564474	ZFINID:	ZDB-GENE-070912-552	Length:	550	Species:	Danio rerio

Alignment Length:	474	Identity:	210/474 - (44%)
Similarity:	293/474 - (61%)	Gaps:	40/474 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSI 76
            |.:.:.|.|...:|:.|..|.::||.:::.  ..|.:..:|.|||||:.:||||.||:||:.||:
Zfish    22 KDYCKRNGLLTLSVLAVMSGCVVGFTLRSL--NLSTQAKIYFSFPGELLMRMLKMLILPLITSSL 84

  Fly    77 TSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKA-SKVL 140
            .|.:..:|...|.::....||||..||..|||:||.||..:.||.|     |:.|....| ..|:
Zfish    85 MSGLSAMDTKASGRLGLLTITYYLWTTFIAVIVGIILVLIIHPGTG-----TEKEGHKAAGGPVM 144

  Fly   141 T-PDTLMDLVRNMFTDNIIQSTMFQHRTEI---------------------YEN--------TSI 175
            | .|.|:||:|||...|:|::|..|::||:                     |||        ..:
Zfish   145 TSADALLDLIRNMIPSNLIEATFQQYKTELVPNFKNSAKSSQANFVYIMPDYENPKMGHPVFLEL 209

  Fly   176 SPAQPMENWEFKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIW 240
            :| .|..:::....:..|.||||:|:||..:|..:|||..:|..|.:....::|.:|.|.:..:|
Zfish   210 TP-PPEIHYKIVPGKSNGMNVLGIVIFSATMGLLLGRMGSRGSPLVNVCLCINECVMKIINAAMW 273

  Fly   241 ISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKL 305
            ..|.|:.||:|.||::|...|...:.||.|||||:.|||:||...:.:.||:.||:.|:.||..|
Zfish   274 YFPFGIVFLVAGKILDMHDPAVLAEKLGMYFITVLAGLFVHGVILLPLFFFVFTRKNPFSYIRGL 338

  Fly   306 SQVLATAFGTGSSSATMPLTIKC-LDNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYR 369
            .|.|..|..|.|||||:|:|:|| |:|..:|.::.|||:|||||||||||||||||||:||||..
Zfish   339 LQALVIALATSSSSATLPITMKCLLENCHVDRKIARFVLPVGATINMDGTALYEAVAAIFIAQVN 403

  Fly   370 EMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTI 434
            |....||.:|.:|||||||||||||||||||||||:||.:|||.|.|:|||:|:||:||||||.|
Zfish   404 EYELDFGQLVTISITATAASIGAAGIPQAGLVTMVIVLTSVGLPPDDISLIVAIDWILDRFRTMI 468

  Fly   435 NVMCDALGTILVNHLSKND 453
            ||:.|||...::.|:.:.|
Zfish   469 NVLGDALAAGIMAHVCRKD 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	206/460 (45%)
slc1a8b	NP_001177745.1	SDF	30..482	CDD:278787	206/459 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	397	1.000	Domainoid score	I716
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1797
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm24560
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980