DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and slc1a1

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001002666.2	Gene:	slc1a1 / 436939	ZFINID:	ZDB-GENE-040718-414	Length:	528	Species:	Danio rerio

Alignment Length:	472	Identity:	212/472 - (44%)
Similarity:	303/472 - (64%)	Gaps:	32/472 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSI 76
            |..::.|.:.:||:|.|.:|..:|.::::.| ..::.|..|..|||||.:||||.:|:||:|||:
Zfish    15 KGLLKRNWILIATIIAVILGIGLGVVVRDYT-SLTQLEKQYFGFPGEILMRMLKMVILPLIVSSM 78

  Fly    77 TSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDK---ASK 138
            .:.:..||..:|.:|..||:.||..|||.||||||.||.|::||     |....::||:   ...
Zfish    79 ITGVAALDSEVSGRIGLRAVVYYISTTIIAVILGIVLVMTIKPG-----VSQSADNIDREGTTPN 138

  Fly   139 VLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYE--------NTSISPAQP-------------ME 182
            |.|.:||:||:||||.:|::|:...|::|:..|        ||:.:.|.|             .:
Zfish   139 VTTVETLLDLIRNMFPENLVQACFQQYKTQRREIEPTKPSINTTNATAFPPFTTIISTVAQNLTK 203

  Fly   183 NWEFKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVA 247
            :::...:..:|.|||||::|.|..|..||:|.|:|::|.:||..|:||.|.|...::...|:|:.
Zfish   204 DYKIVGSYSDGINVLGLIVFCVTFGLVIGKMGERGRILLEFFDALNEATMRIVQIIMCYMPIGIF 268

  Fly   248 FLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATA 312
            |||||||||::. ....:.||.|.:||:.||.:|....:.:|:|:..|:.|:.:...::|.|.||
Zfish   269 FLIAAKIIEVDD-WEIFRKLGLYMVTVLSGLAIHSIIFLPLIYFVFVRKNPFTFTLGMAQALVTA 332

  Fly   313 FGTGSSSATMPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFG 376
            ....|||||:|:|.:|. :|..||.|:||||:||||||||||||||||||::||||......:.|
Zfish   333 LMISSSSATLPVTFRCAEENNRIDKRITRFVLPVGATINMDGTALYEAVASIFIAQLNNYDLNAG 397

  Fly   377 TIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDAL 441
            .||.:|||||.|||||||:|.||:||||:||..|||...||:||||||||||||||.|||:.||.
Zfish   398 QIVTISITATVASIGAAGVPNAGMVTMVIVLTAVGLPADDVTLIIAVDWLLDRFRTMINVLGDAY 462

  Fly   442 GTILVNHLSKNDLASVD 458
            |..:|..|||.:|..:|
Zfish   463 GAGIVQKLSKRELERMD 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	205/453 (45%)
slc1a1	NP_001002666.2	SDF	23..470	CDD:278787	205/453 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	397	1.000	Domainoid score	I716
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1797
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm24560
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	LDO	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880