DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and Slc1a7

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001102443.1	Gene:	Slc1a7 / 366432	RGDID:	1311928	Length:	570	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	224/542 - (41%)
Similarity:	317/542 - (58%)	Gaps:	66/542 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSI 76
            :|..:.|.|.:.:|:.|.||.|:||.::  |...|.:||.|..||||:.:||||.||:||:|||:
  Rat    21 RAVCRHNGLLILSVLSVIVGCLLGFFLR--TQRLSPQEISYFQFPGELLMRMLKMLILPLVVSSL 83

  Fly    77 TSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASK--V 139
            .|.:..||...||::....:.||..||..||::||.:|:.:.||..|     |.|:.:::.|  :
  Rat    84 MSGLASLDAKTSSRLGILTVAYYLWTTFLAVVVGIIMVSIIHPGGAA-----QKETTEQSGKPVM 143

  Fly   140 LTPDTLMDLVRNMFTDNIIQSTMFQHRTE---------------------IY----------ENT 173
            .:.|.|:|||||||..|::::|..|:||:                     ||          :|.
  Rat   144 SSADALLDLVRNMFPANLVEATFKQYRTKTTPVIKSPKGAAEEAPPRGIVIYGVQEDNGSRVQNF 208

  Fly   174 SISPAQPME-NWEFKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSW 237
            ::....|.| .::.:....:|.||||:|:||..:|..:|||.:.|..|..|...|:|::|.|.:.
  Rat   209 ALDLTPPPEIVYKSEPGTSDGMNVLGIVIFSATMGIMLGRMGDSGTPLVSFCQCLNESVMKIVAV 273

  Fly   238 VIWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYI 302
            ..|..|.|:.||||.||:||:...|..:.||:|.:||:.||.:||...:.:::||.||:.|..:|
  Rat   274 AGWYFPFGIVFLIAGKILEMDDPKAVGKKLGFYAVTVVCGLVVHGLLILPLLYFLITRKNPIVFI 338

  Fly   303 AKLSQVLATAFGTGSSSATMPLTIKC-LDNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIA 366
            ..:.|.|..|..|.|||||:|:|.|| |:|..||.|:.|||:|||||||||||||||||||:|||
  Rat   339 RGVLQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIA 403

  Fly   367 QYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFR 431
            |.......||.|:.:|||||||||||||||||||||||:||.:|||...|::|||||||.|||||
  Rat   404 QVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDINLIIAVDWALDRFR 468

  Fly   432 TTINVMCDALGTILVNHLSKNDLA---SVDRL---NAEP---HELLELGPNG--HEMKEXRQSSL 485
            |.|||:.|||...::.|:.:.|.|   ..::|   ..:|   .|::....||  ..:.|..:.:|
  Rat   469 TMINVLGDALAAGIMAHICRKDFAQDMGTEKLLPCETKPVTLQEIVAAQQNGCVKSVAEASELTL 533

  Fly   486 GAYNRKRXVDMSRLWACFHILP 507
            |.             .|.|.:|
  Rat   534 GP-------------KCPHHIP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	208/463 (45%)
Slc1a7	NP_001102443.1	SDF	29..486	CDD:278787	208/463 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I764
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1859
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm46063
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980