DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and Eaat2

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	175/490 - (35%)
Similarity:	292/490 - (59%)	Gaps:	31/490 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FKAFMQENVLTMATVIGVFVGGLIGFIIK--NSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLV 73
            ::.::.||::.:.|:.||.:|.::|..::  |..|:    .||.||:|||:|:|:||.:|:||::
  Fly    42 YRRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGD----SIMLISYPGELFMRVLKLMILPLVI 102

  Fly    74 SSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASK 138
            ||:.:....|:..|:.|||.|.:.|:..|:.....|||.||..:.|| ...:......|.|:.:.
  Fly   103 SSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPG-NPDLHNADDRSTDRRAV 166

  Fly   139 VLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSI---------------SPAQPMENWEFKS 188
            .|. |:|:||.||:|.||:.|:::.|..|......||               |.||.:.....:.
  Fly   167 NLL-DSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTED 230

  Fly   189 A-------QREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGV 246
            .       .|.|:|.||:|.|.::.||.:|.:.:|||::.|||..:.|.:|.:.:.|:|::|:|:
  Fly   231 VVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGI 295

  Fly   247 AFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLAT 311
            :.:||.||:.:..:...:..|.|:.:||.||:|::.|..:..|:|:..||.|:::.|.|.|.:.|
  Fly   296 SSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLT 360

  Fly   312 AFGTGSSSATMPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSF 375
            ||.|.|::|.:|:|.:|: :.:.:|||:||||:|:|..|||||||||.|||::||||...|...|
  Fly   361 AFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGF 425

  Fly   376 GTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDA 440
            |.::.|.:|:||||:.:|.:|.|.||.:::||..:....:||:|:.||||.:||.|||.|::.|.
  Fly   426 GELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDC 490

  Fly   441 LGTILVNHLSKNDLASVDRLNAEPHELLELGPNGH 475
            ....:|..||:.:|.::|..:....::....||||
  Fly   491 YTAAVVEELSRKELMALDAASVNYQDMPAGTPNGH 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	165/453 (36%)
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	164/450 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467248
Domainoid	1	1.000	149	1.000	Domainoid score	I194
eggNOG	1	0.900	-	-		E1_COG1301
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I222
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		mtm9755
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	P	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
	11	10.800