DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat1 and Slc1a1

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_038957786.1	Gene:	Slc1a1 / 25550	RGDID:	3696	Length:	527	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	218/481 - (45%)
Similarity:	310/481 - (64%)	Gaps:	27/481 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRPKQDGGKFKAFMQENVLTMATVIGVFVGG----LIGFIIKNSTGEWSKREIMYISFPGEIFL 61
            |.:|...|..::.|::.:.|.::||..|.:|.    ::|.:::..: |.|..:..|.:|||||.:
  Rat     1 MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGESRAIVVGVLVRGHS-ELSNLDKFYFAFPGEILM 64

  Fly    62 RMLKCLIVPLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIV 126
            ||||.:|:||::||:.:.:..||.::|.||..||:.|||.||:.||||||.||.:::||...|:.
  Rat    65 RMLKLVILPLIISSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVN 129

  Fly   127 ETQTESIDKASKVLTPDTLMDLVRNMFTDNIIQSTMFQHR----------------TEIYENTSI 175
            |.....  |..:|.|.|.::||:||||.:|::|:...|::                ||:...|::
  Rat   130 EINRTG--KTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPASDPGGNQTEVSVTTAM 192

  Fly   176 SPAQPMENWEFK--SAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWV 238
            :.....:..|:|  ....:|.|||||::|.::.|..||:|.||||:|.|||..||:|.|.|...:
  Rat   193 TTMSENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQII 257

  Fly   239 IWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIA 303
            :...|:|:.||||.||||:|. ....:.||.|..||:.||.:|....:.:|:|:..|:.|:|:..
  Rat   258 MCYMPIGILFLIAGKIIEVED-WEIFRKLGLYMATVLSGLAIHSLVVLPLIYFIVVRKNPFRFAL 321

  Fly   304 KLSQVLATAFGTGSSSATMPLTIKCLDNMG-IDPRVTRFVIPVGATINMDGTALYEAVAALFIAQ 367
            .::|.|.||....|||||:|:|.:|.:... :|.|:||||:|||||||||||||||||||:||||
  Rat   322 GMAQALLTALMISSSSATLPVTFRCAEEKNHVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQ 386

  Fly   368 YREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRT 432
            ...|..|.|.|:.:|||||||||||||:|||||||||:||..|||..:||:||||||||||||||
  Rat   387 LNGMDLSIGQIITISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRT 451

  Fly   433 TINVMCDALGTILVNHLSKNDLASVD 458
            .:||:.||.||.:|..|||.:|..||
  Rat   452 MVNVLGDAFGTGIVEKLSKKELEQVD 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	208/451 (46%)
Slc1a1	XP_038957786.1	SDF	20..468	CDD:395299	208/451 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I764
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1859
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm46063
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	LDO	PTHR11958
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880