DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat1 and Slc1a7

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_666367.3	Gene:	Slc1a7 / 242607	MGIID:	2444087	Length:	559	Species:	Mus musculus

Alignment Length:	545	Identity:	223/545 - (40%)
Similarity:	317/545 - (58%)	Gaps:	65/545 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSAI 80
            :.|.|.:.:|:.|.||.|:||.::  |...|.:||.|..||||:.:||||.||:||:|||:.|.:
Mouse    15 KHNGLLILSVLSVIVGCLLGFFLR--TQRLSPQEISYFQFPGELLMRMLKMLILPLVVSSLMSGL 77

  Fly    81 GGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASK--VLTPD 143
            ..||...||::....:.||..||..||::||.:|:.:.||..|     |.|:.:::.|  :.:.|
Mouse    78 ASLDAKTSSRLGILTVAYYLWTTFLAVVVGIIMVSIIHPGGAA-----QKETTEQSGKPVMSSAD 137

  Fly   144 TLMDLVRNMFTDNIIQSTMFQHRTE--------------------IY----------ENTSISPA 178
            .|:|||||||..|::::|..|:||:                    ||          :|.::...
Mouse   138 ALLDLVRNMFPANLVEATFKQYRTKTTPVIKSPRGAAEEAPRRIVIYGVQEDNGSRVQNFALDLT 202

  Fly   179 QPME-NWEFKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWIS 242
            .|.| .::.:....:|.||||:|:||..:|..:|||.:.|..|..|...|:|::|.|.:...|..
Mouse   203 PPPEIVYKSEPGTSDGMNVLGIVIFSATMGIMLGRMGDSGTPLVSFCQCLNESVMKIVAVAGWYF 267

  Fly   243 PLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQ 307
            |.|:.||||.||:||:...|..:.||:|.:||:.||.:||...:.:::||.|::.|..:|..:.|
Mouse   268 PFGIVFLIAGKILEMDDPKAVGKKLGFYAVTVVCGLVVHGLLILPLLYFLITKKNPIVFIRGVLQ 332

  Fly   308 VLATAFGTGSSSATMPLTIKC-LDNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREM 371
            .|..|..|.|||||:|:|.|| |:|..||.|:.|||:|||||||||||||||||||:||||....
Mouse   333 ALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNY 397

  Fly   372 SYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINV 436
            ...||.|:.:|||||||||||||||||||||||:||.:|||...|::|||||||.||||||.|||
Mouse   398 ELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDINLIIAVDWALDRFRTMINV 462

  Fly   437 MCDALGTILVNHLSKNDLA---SVDRL---NAEP---HELLELGPNG--HEMKEXRQSSLGAYNR 490
            :.|||...::.|:.:.|.|   ..::|   ..:|   .|::....||  ..:.| .:.:||.
Mouse   463 LGDALAAGIMAHICRKDFAQDMGTEKLLPCETKPVTLQEIVAAQQNGCVKSVAEASELTLGP--- 524

  Fly   491 KRXVDMSRLWACFHILPSNDSDSDD 515
                      .|.|.:|......:|
Mouse   525 ----------TCPHHIPVQVEQDED 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	207/462 (45%)
Slc1a7	NP_666367.3	SDF	19..475	CDD:334043	207/462 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I784
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1910
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm43973
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980