DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and Slc1a5

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_033227.2	Gene:	Slc1a5 / 20514	MGIID:	105305	Length:	555	Species:	Mus musculus

Alignment Length:	473	Identity:	175/473 - (36%)
Similarity:	285/473 - (60%)	Gaps:	24/473 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MQENVLTMATVIGVFVGGLIGFIIKNSTG--EWSKREIMYISFPGEIFLRMLKCLIVPLLVSSIT 77
            ::.|:|.:.||..|..|..:|..:..:.|  ......:...:||||:.||:||.:|:||:|.|:.
Mouse    50 IRANLLVLLTVAAVVAGVGLGLGVSAAGGADALGPARLTAFAFPGELLLRLLKMIILPLVVCSLI 114

  Fly    78 SAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASKVLTP 142
            .....||.|...::...|:.::.|||:.|..||:.|...|:||.....:.:..:|:........|
Mouse   115 GGAASLDPSALGRVGAWALLFFLVTTLLASALGVGLALALKPGAAVTAITSINDSVVDPCARSAP 179

  Fly   143 -----DTLMDLVRNMFTDNIIQSTMFQHRTEIYE--NTSISPAQPMENWEFKS------AQREGS 194
                 |:.:|||||:|..|:: |..|:.....||  :.|....|.....|..|      .:.||.
Mouse   180 TKEVLDSFLDLVRNIFPSNLV-SAAFRSFATSYEPKDNSCKIPQSCIQREINSTMVQLLCEVEGM 243

  Fly   195 NVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMES 259
            |:||||:|:::.|..:.::..:|:||..||.:.::|.|.:.||::|.:|:|:.||:|:||:||:.
Mouse   244 NILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPVGILFLVASKIVEMKD 308

  Fly   260 IAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPL 324
            :.....|||.|.:..::|..:||...:.:|:||.||:.|||::..:...|||||||.|||||:||
Mouse   309 VRQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSSATLPL 373

  Fly   325 TIKCLDNM-GIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAA 388
            .:||::.. |:...::||::|:|||:||||.||::.|||:||||...:|..|..|:.:.:||||:
Mouse   374 MMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATAS 438

  Fly   389 SIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGT-ILVNHLSKN 452
            |:||||||..|::|:.::|:.|.|..||:|||:|||||:||..|.:||..||.|. :|.:::.:.
Mouse   439 SVGAAGIPAGGVLTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRT 503

  Fly   453 DLASVDRLNAEPHELLEL 470
            .:.|     :|| ||:::
Mouse   504 KMPS-----SEP-ELIQV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	169/445 (38%)
Slc1a5	NP_033227.2	SDF	55..496	CDD:278787	168/441 (38%)
Slc1a5	NP_033227.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.790