DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat1 and Slc1a3

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_683740.1	Gene:	Slc1a3 / 20512	MGIID:	99917	Length:	543	Species:	Mus musculus

Alignment Length:	508	Identity:	226/508 - (44%)
Similarity:	322/508 - (63%)	Gaps:	51/508 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIV 69
            |:|   .|:::..|...:.||..|.||.::||.::  ..:.|.||:.|.|||||:.:|||:.|::
Mouse    38 KED---VKSYLFRNAFVLLTVTAVIVGTILGFALR--PYKMSYREVKYFSFPGELLMRMLQMLVL 97

  Fly    70 PLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESID 134
            ||::||:.:.:..||...|.|:..||:.||..|||.||::||.:|..:.||:|.|      |::.
Mouse    98 PLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTK------ENMY 156

  Fly   135 KASKVL---TPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSIS-PAQPMEN------------ 183
            :..|::   ..|..:||:||||..|::::...|.:|. ||..|.. |.|..|.
Mouse   157 REGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTS-YEKRSFKVPIQSNETLLGAVINNVSEA 220

  Fly   184 WEFKSAQRE----------GSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWV 238
            .|..:..||          |.|.||||:||:..|..||.|:|:||.|::||.:|:||:|.:.:.:
Mouse   221 METLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVI 285

  Fly   239 IWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIA 303
            :|.:|||:.||||.||:|||.:......|..|.:||::||.:|....:.:::||.||:.|:.:|.
Mouse   286 MWYAPLGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIG 350

  Fly   304 KLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQ 367
            .|.|.|.||.||.|||||:|:|.||| :|.|:|.|:||||:||||||||||||||||:||:||||
Mouse   351 GLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQ 415

  Fly   368 YREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRT 432
            ......:||.|:.:|||||||||||||||||||||||:||.:|||...|::|||||||.|||.||
Mouse   416 VNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT 480

  Fly   433 TINVMCDALGTILVNHLSKNDLASVDRLNAEPHELLELGPN---GHEMKEXRQ 482
            |.||:.|:||..:|.|||:::|.:.|         :|:|.:   .:|||: .|
Mouse   481 TTNVLGDSLGAGIVEHLSRHELKNRD---------VEMGNSVIEENEMKKPYQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	211/455 (46%)
Slc1a3	NP_683740.1	SDF	50..497	CDD:278787	211/455 (46%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:O59010	363..365		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	443..447		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..543		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I784
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1910
Isobase	1	0.950	-	0	Normalized mean entropy	S3279
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm43973
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5013
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.860