DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and Slc1a1

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_033225.1	Gene:	Slc1a1 / 20510	MGIID:	105083	Length:	523	Species:	Mus musculus

Alignment Length:	477	Identity:	216/477 - (45%)
Similarity:	309/477 - (64%)	Gaps:	23/477 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRPKQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLK 65
            |.:|...|..::.|::.:.|.::||..|.:|.::|.:::..: |.|..:..|.:|||||.:||||
Mouse     1 MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVLGVVVRGHS-ELSNLDKFYFAFPGEILMRMLK 64

  Fly    66 CLIVPLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQT 130
            .:|:||:|||:.:.:..||.::|.||..||:.|||.||:.||||||.||.:::||...|:  ...
Mouse    65 LVILPLIVSSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKV--NDI 127

  Fly   131 ESIDKASKVLTPDTLMDLVRNMFTDNIIQSTMFQHR----------------TEIYENTSISPAQ 179
            ....|..:|.|.|.::||:||||.:|::|:...|::                ||:...|:::...
Mouse   128 NRTGKTPEVSTMDAMLDLIRNMFPENLVQACFQQYKTKREEVKPVGDPGGNATEVSVTTAMTTMS 192

  Fly   180 PMENWEFK--SAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWIS 242
            ..:..|:|  ....:|.|||||::|.::.|..||:|.||||:|.|||..||:|.|.|...::...
Mouse   193 ENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYM 257

  Fly   243 PLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQ 307
            |:|:.||||.||||:|. ....:.||.|..||:.||.:|....:.:::|:..|:.|:|:...::|
Mouse   258 PIGILFLIAGKIIEVED-WEIFRKLGLYMATVLSGLAIHSLIVLPLLYFIVVRKNPFRFALGMAQ 321

  Fly   308 VLATAFGTGSSSATMPLTIKCLDNMG-IDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREM 371
            .|.||....|||||:|:|.:|.:... :|.|:||||:|||||||||||||||||||:||||...:
Mouse   322 ALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGL 386

  Fly   372 SYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINV 436
            ..|.|.||.:|||||||||||||:|||||||||:||..|||..:||:||||||||||||||.:||
Mouse   387 DLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNV 451

  Fly   437 MCDALGTILVNHLSKNDLASVD 458
            :.||.||.:|..|||.:|..:|
Mouse   452 LGDAFGTGIVEKLSKKELEQMD 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	207/447 (46%)
Slc1a1	NP_033225.1	SDF	51..464	CDD:278787	199/415 (48%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	330..332		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	410..414		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I784
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1910
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm43973
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	LDO	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.880