DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and slc1a7b

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001177689.1	Gene:	slc1a7b / 100463517	ZFINID:	ZDB-GENE-101111-7	Length:	580	Species:	Danio rerio

Alignment Length:	482	Identity:	213/482 - (44%)
Similarity:	298/482 - (61%)	Gaps:	44/482 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVS 74
            :.|...::|.|.:.:|:.|.:|.|:||.:::.  ..|::|:.|..||||:.:||||.||:||:||
Zfish    11 RVKGVCKQNGLLILSVLAVVIGCLLGFFLRSK--NLSEQEVKYFQFPGELLMRMLKMLILPLVVS 73

  Fly    75 SITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASKV 139
            |:.|.:..||...||::....::||..||..||::||.:|..:.||..|:    :.:|.|....:
Zfish    74 SLMSGLAALDAKCSSRLGLITVSYYLWTTFLAVVVGIVMVLIIHPGGMAQ----KEDSEDSGKPI 134

  Fly   140 L-TPDTLMDLVRNMFTDNIIQSTMFQHRTE-------------------------IY-----ENT 173
            : :.|.|:||:||||..|::|:|..|:||.                         ||     ..|
Zfish   135 MSSADALLDLIRNMFPANLVQATFQQYRTNSVPIMKAPKTTVATSLAESTTRRALIYGIQDDNGT 199

  Fly   174 SISPAQ----PMENWEFKS--AQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMM 232
            .|...|    |..:..|::  ...||.||||:|:||..:|..:|||...|..|.:|..:|:||::
Zfish   200 DIQNFQLDLTPPPDVVFRTLPGTSEGMNVLGIVIFSATMGIMLGRMGPNGSALVNFCQSLNEAVL 264

  Fly   233 TITSWVIWISPLGVAFLIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRL 297
            .|.:.|||..|.|:.||:|.||:||...:|..:.||:|.|||::||.|||...:..::|..|::.
Zfish   265 KIVAIVIWYFPFGIVFLVAGKILEMSDPSAMGKKLGFYAITVVMGLILHGLFILPSMYFFITKKS 329

  Fly   298 PYRYIAKLSQVLATAFGTGSSSATMPLTIKC-LDNMGIDPRVTRFVIPVGATINMDGTALYEAVA 361
            |..||..:.|.|..:..|.|||||:|:|.|| |:|..||.|:.|||:||||||||||||||||||
Zfish   330 PIVYIRGILQALLISLATSSSSATLPITFKCLLENNHIDRRIIRFVLPVGATINMDGTALYEAVA 394

  Fly   362 ALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWL 426
            |:||||.......||.|:.:|||||||||||||||||||||||:||.:|||...|::|||||||.
Zfish   395 AIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWA 459

  Fly   427 LDRFRTTINVMCDALGTILVNHLSKND 453
            ||||||.:|||.|||.|.::.|:.:.|
Zfish   460 LDRFRTMVNVMGDALATGIMAHICRKD 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	209/466 (45%)
slc1a7b	NP_001177689.1	SDF	21..482	CDD:278787	209/466 (45%)
slc1a7b	NP_001177689.1	RNA_polI_A34	<529..>571	CDD:285426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	397	1.000	Domainoid score	I716
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1797
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm24560
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.980