DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and slc1a9

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001177688.1	Gene:	slc1a9 / 100463516	ZFINID:	ZDB-GENE-101111-9	Length:	671	Species:	Danio rerio

Alignment Length:	462	Identity:	199/462 - (43%)
Similarity:	303/462 - (65%)	Gaps:	19/462 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIV 69
            :||.|    ::..|:|.:.||:||..|.::|.::: ...:.....:|.:||||::.:||||.||:
Zfish    29 QQDCG----WLSRNLLLVLTVLGVIAGTVMGMMLR-YVPDLDTNTLMMVSFPGDVLMRMLKMLIL 88

  Fly    70 PLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESID 134
            ||::||:.:.:.|||...|.::.|||:.||..||:.|.:||:.||..:.|| ..|:...|..|..
Zfish    89 PLIISSLITGLAGLDARSSGRMGTRAMVYYMSTTVIAAVLGVILVLGIHPG-NPKLRSGQVSSAP 152

  Fly   135 KASKVLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQPMENW-------EFKSAQRE 192
            :..:|.:.|..:||:||:|.:|::|: .||....:.:..:|    |::|.       ..|...:.
Zfish   153 RNQEVSSLDAFLDLIRNLFPENLVQA-CFQQVQTVLKKVAI----PVQNQTEPILVNRKKLELKW 212

  Fly   193 GSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEM 257
            |.|||||:.|.:..|..:|:|.|:|:|:.|||..|:|.:|.:.|.::|.||:|:|.||..||..:
Zfish   213 GMNVLGLIGFFITFGICMGKMGERGKLMSDFFNILNEIIMKMVSMIMWYSPVGIASLICGKIAAI 277

  Fly   258 ESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATM 322
            ..:....:.||.|.:||::||.:||...:.||||..||:.|:.:.:.:.|...||.||.||:.|:
Zfish   278 GDLEVVARQLGMYMVTVIVGLIIHGGLILPVIFFAVTRKNPFMFYSGIFQAWITALGTASSAGTL 342

  Fly   323 PLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITAT 386
            |:|.:|| :|:.||.||||||:|:|||||||||||||||||:||||..:::...|.|:.||:|||
Zfish   343 PVTFRCLEENLKIDKRVTRFVLPIGATINMDGTALYEAVAAIFIAQMNDIALDGGQIITVSMTAT 407

  Fly   387 AASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLSK 451
            .||:|||.||.||||||:::|..|||..:|:||::||||||||.||:|||:.|:.|..:|:|||:
Zfish   408 LASVGAASIPSAGLVTMLLILTAVGLPTQDISLLVAVDWLLDRMRTSINVVGDSFGAGIVDHLSR 472

  Fly   452 NDLASVD 458
            .:||.:|
Zfish   473 AELAVID 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	189/436 (43%)
slc1a9	NP_001177688.1	SDF	49..470	CDD:278787	184/427 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920