DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat1 and slc1a5

DIOPT Version :9

Sequence 1:	NP_001369123.1	Gene:	Eaat1 / 34251	FlyBaseID:	FBgn0026439	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001177684.1	Gene:	slc1a5 / 100002129	ZFINID:	ZDB-GENE-070501-4	Length:	539	Species:	Danio rerio

Alignment Length:	479	Identity:	180/479 - (37%)
Similarity:	296/479 - (61%)	Gaps:	28/479 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TRPKQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKC 66
            :.|:....|.|.|:..|:|.:.||..|.||.|||..::|:  ..|:.:|:|..||||:.:|:||.
Zfish    35 SEPESTAQKVKRFVLANLLVILTVSAVIVGVLIGLGVRNA--GLSRTQIIYFGFPGELLIRLLKM 97

  Fly    67 LIVPLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQG----AKIVE 127
            :|:||:|.|:.|....:|.....|:...|:.::.|||:.|..:|:.:...:.||..    :::..
Zfish    98 IIIPLVVCSLVSGAASIDPKALGKLGGWAMLFFLVTTLIASAIGVIMAFIIHPGSSDGKMSQLNA 162

  Fly   128 TQTESIDKASKVLTPDTLMDLVRNMFTDNIIQSTMFQHRTEIYE------NTSISPAQ-PMENWE 185
            ....|:.:|..|:  |:.:||:||:|..|:: :..||.....|:      |:|:...: |:
Zfish   163 QDDSSVPEAKDVI--DSFLDLIRNIFPSNLV-AAAFQSYATGYKFVKNDTNSSVLLEKVPV---- 220

  Fly   186 FKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLI 250
              ....:|.|:|||::|::..|..:.::.|:|.:|..||.:.:||.|.:.||::|.:|||:.||:
Zfish   221 --GTDVDGMNILGLIVFAMAFGVALRKLGEEGVILMKFFNSFNEATMVLVSWIMWYAPLGIMFLV 283

  Fly   251 AAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGT 315
            ||||:|||.::....|||.|....:||..:||...:.:|:|:.||:.||.::..|...|||||||
Zfish   284 AAKIVEMEDVSLLFTSLGKYIACCVIGHAIHGLLVLPLIYFIITRKNPYTFLLGLVTALATAFGT 348

  Fly   316 GSSSATMPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIV 379
            .|||||:||.:||: :|.|:...::||::|:|||:||||.|.::.|||:||||...:..:|..::
Zfish   349 SSSSATLPLMMKCVEENNGVSKHISRFILPIGATVNMDGAACFQCVAAVFIAQLNGIPLNFVQVI 413

  Fly   380 AVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTI 444
            .:.:||||:|:||||||..|::|:.::|::|||...|:|||:|||||:||..|.|||..||.|..
Zfish   414 TILVTATASSVGAAGIPAGGVLTLAIILESVGLPTNDLSLILAVDWLVDRTCTVINVEGDAYGAG 478

  Fly   445 LVNHL-----SKNDLASVDRLNAE 463
            |:.:|     :||:...:|::..|
Zfish   479 LLQYLVDRHPNKNEEEELDKIRVE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat1	NP_001369123.1	SDF	20..449	CDD:395299	170/440 (39%)
slc1a5	NP_001177684.1	SDF	53..480	CDD:278787	169/437 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	397	1.000	Domainoid score	I716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1797
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.980