Protein Alignment IDUA and Idua

DIOPT Version :10

• Sequence 1: XP_054205907.1
• Gene: IDUA / 3425
• HGNCID: 5391
• Length: 722
• Species: Homo sapiens
• Sequence 2: XP_038948073.1
• Gene: Idua / 360904
• RGDID: 1310943
• Length: 644
• Species: Rattus norvegicus
• Alignment Length: 719
• Identity: 465/719 - (64%)
• Similarity: 524/719 - (72%)
• Gaps: 85/719 - (11%)

Human     1 MRPLRPRAALLALLASLLAAPPVAPAEAPHLVQVDAARALWPLRRFWRSTGFCPPLPHSQADQYV 65
            |||.||.:|:|...|:.||: |:|.||.|:||:|||||.|.||..|||||||||||||.|||||.
  Rat     1 MRPPRPASAMLIFFAAFLAS-PLALAETPYLVRVDAARPLRPLLPFWRSTGFCPPLPHDQADQYD 64

Human    66 LSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVT-TRGSTGRGLSYNFTHLDGYLDLLRENQLLPG 129
            |||||||||||:|||||.||:|||.||||:|:| :|.|:|:||.|||||||.:||||.|||||||
  Rat    65 LSWDQQLNLAYIGAVPHSGIEQVRIHWLLDLITASRKSSGQGLIYNFTHLDAFLDLLMENQLLPG 129

Human   130 FELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMT 194
            ||||||.||:||||||||||||||||||.|||||||:|||.:|||||||||||||||||||||||
  Rat   130 FELMGSPSGYFTDFEDKQQVFEWKDLVSLLARRYIGKYGLTNVSKWNFETWNEPDHHDFDNVSMT 194

Human   195 MQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYI 259
            .|||||||||||||||.|||.|||||||||||..||||:.|.||.||.:||||||||.|||||||
  Rat   195 TQGFLNYYDACSEGLRIASPTLRLGGPGDSFHPLPRSPMCWSLLGHCANGTNFFTGEVGVRLDYI 259

Human   260 SLHRKVRPAPPSAPVFCALSRCAPGRADPGGAEAAPPAGCAQLHLHPGAGEGRRAADP--AALPQ 322
            |||:|                                          |||......:.  |.:.|
  Rat   260 SLHKK------------------------------------------GAGSSIAILEQEVAVVEQ 282

Human   323 VRGHPHLQRRGGPAGGLVPATAVEGGRDLRGHGGEGGP-----AQRPARPPATFLPRRDRRAVAA 382
            ::             .|.|..     :|...:..|..|     ..:|.|...|:      .|:..
  Rat   283 IQ-------------QLFPKF-----KDTPIYNDEADPLVGWSLPQPWRADVTY------AALVV 323

Human   383 PPGPSCPGHPQVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPH 447
                      :|||||||||.||::|:..|.|||||||||||||:||:|||||||||||||.|||
  Rat   324 ----------KVIAQHQNLLFANSSSSMRYILLSNDNAFLSYHPYPFSQRTLTARFQVNNTHPPH 378

Human   448 VQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYAS 512
            ||||||||||.|||:||||.|||||||.:||.|||||||||||||.|.|:||::|||..||||.|
  Rat   379 VQLLRKPVLTVMGLMALLDGEQLWAEVLKAGAVLDSNHTVGVLASTHHPEGPSEAWRTTVLIYTS 443

Human   513 DDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAE 577
            |||..|||.|:.|.|.|||||||..||||..||||.|.||...|:.:|:||||:|||||:||..|
  Rat   444 DDTHIHPNDSIPVILHLRGVPPGLELVYVVLYLDNQLSSPYSAWQHMGQPVFPSAEQFRQMRMVE 508

Human   578 DPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHV 642
            ||||.||||.||.|||||...|.:|||:|||:||||.:|||||:||||||||:||||||||||||
  Rat   509 DPVAEAPRPFPARGRLTLYRKLPVPSLMLVHLCARPLEPPGQVSRLRALPLTRGQLVLVWSDEHV 573

Human   643 GSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPY 707
            ||||||||||||||.|:.|.|::|:|||||||||||||..|||.|||||:|||||||||||||.|
  Rat   574 GSKCLWTYEIQFSQKGEVYAPINRRPSTFNLFVFSPDTAVVSGFYRVRAVDYWARPGPFSDPVTY 638

Human   708 LEVP 711
            |:.|
  Rat   639 LDTP 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDUA	XP_054205907.1	Glycosyl hydrolases	30..594	CDD:474034	356/571 (62%)
		FN3	<616..>719	CDD:442628	80/96 (83%)
Idua	XP_038948073.1	Glyco_hydro_39	29..525	CDD:426141	356/571 (62%)