Protein Alignment IDUA and Idua

DIOPT Version :10

• Sequence 1: XP_054205907.1
• Gene: IDUA / 3425
• HGNCID: 5391
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_032351.2
• Gene: Idua / 15932
• MGIID: 96418
• Length: 643
• Species: Mus musculus
• Alignment Length: 718
• Identity: 473/718 - (65%)
• Similarity: 523/718 - (72%)
• Gaps: 84/718 - (11%)

Human     1 MRPLRPRAALLALLASLLAAPPVAPAEAPHLVQVDAARALWPLRRFWRSTGFCPPLPHSQADQYV 65
            |||.||.:|:|...|:.||| |:|.||:|:||:|||||.|.||..|||||||||||||.|||||.
Mouse     1 MRPPRPSSAMLTFFAAFLAA-PLALAESPYLVRVDAARPLRPLLPFWRSTGFCPPLPHDQADQYD 64

Human    66 LSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGF 130
            |||||||||||:|||||.||:|||.||||:|:|.|.|.|:||.|||||||.:||||.||||||||
Mouse    65 LSWDQQLNLAYIGAVPHSGIEQVRIHWLLDLITARKSPGQGLMYNFTHLDAFLDLLMENQLLPGF 129

Human   131 ELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTM 195
            |||||.||:||||:|||||||||||||.|||||||||||.||||||||||||||||||||||||.
Mouse   130 ELMGSPSGYFTDFDDKQQVFEWKDLVSLLARRYIGRYGLTHVSKWNFETWNEPDHHDFDNVSMTT 194

Human   196 QGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYIS 260
            |||||||||||||||.|||.|:|||||||||..||||:.|.||.||.:||||||||.||||||||
Mouse   195 QGFLNYYDACSEGLRIASPTLKLGGPGDSFHPLPRSPMCWSLLGHCANGTNFFTGEVGVRLDYIS 259

Human   261 LHRKVRPAPPSAPVFCALSRCAPGRADPGGAEAAPPAGCAQLHLHPGAGEGRRAADP--AALPQV 323
            ||:|                                          |||......:.  |.:.||
Mouse   260 LHKK------------------------------------------GAGSSIAILEQEMAVVEQV 282

Human   324 RGHPHLQRRGGPAGGLVPATAVEGGRDLRGHGGEGGP-----AQRPARPPATFLPRRDRRAVAAP 383
            :             .|.|..     :|...:..|..|     ..:|.|...|:      .|:..
Mouse   283 Q-------------QLFPEF-----KDTPIYNDEADPLVGWSLPQPWRADVTY------AALVV- 322

Human   384 PGPSCPGHPQVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHV 448
                     :|||||||||.||::|:..|.|||||||||||||:||:|||||||||||||.||||
Mouse   323 ---------KVIAQHQNLLFANSSSSMRYVLLSNDNAFLSYHPYPFSQRTLTARFQVNNTHPPHV 378

Human   449 QLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYASD 513
            |||||||||.|||:||||.||||||||:||.|||||||||||||.|.|:|.|.||...||||.||
Mouse   379 QLLRKPVLTVMGLMALLDGEQLWAEVSKAGAVLDSNHTVGVLASTHHPEGSAAAWSTTVLIYTSD 443

Human   514 DTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAED 578
            ||.||||.|:.|||||||||||..|||:..||||.|.||...|:.:|:||||:||||||||..||
Mouse   444 DTHAHPNHSIPVTLRLRGVPPGLDLVYIVLYLDNQLSSPYSAWQHMGQPVFPSAEQFRRMRMVED 508

Human   579 PVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVG 643
            |||.||||.||.|||||...|.:|||||||||.||.||||||:||||||||.|||:||||||.||
Mouse   509 PVAEAPRPFPARGRLTLHRKLPVPSLLLVHVCTRPLKPPGQVSRLRALPLTHGQLILVWSDERVG 573

Human   644 SKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYL 708
            |||||||||||||.|:.|.|::|:|||||||||||||..|||||||||||||||||||||||.||
Mouse   574 SKCLWTYEIQFSQKGEEYAPINRRPSTFNLFVFSPDTAVVSGSYRVRALDYWARPGPFSDPVTYL 638

Human   709 EVP 711
            :||
Mouse   639 DVP 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDUA	XP_054205907.1	Glycosyl hydrolases	30..594	CDD:474034	360/570 (63%)
		FN3	<616..>719	CDD:442628	81/96 (84%)
Idua	NP_032351.2	Glyco_hydro_39	29..524	CDD:426141	360/570 (63%)