Protein Alignment IDUA and idua

DIOPT Version :10

• Sequence 1: XP_054205907.1
• Gene: IDUA / 3425
• HGNCID: 5391
• Length: 722
• Species: Homo sapiens
• Sequence 2: XP_002935502.3
• Gene: idua / 100488103
• XenbaseID: XB-GENE-986805
• Length: 632
• Species: Xenopus tropicalis
• Alignment Length: 685
• Identity: 315/685 - (45%)
• Similarity: 429/685 - (62%)
• Gaps: 85/685 - (12%)

Human    31 LVQVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLE 95
            ::::|..:....|:.||:||||||||||.:::.|.|..||||||||:.::|.:||:|||.||||:
 Frog    23 IIKIDPTKGRNQLKHFWKSTGFCPPLPHDKSETYFLGKDQQLNLAYISSIPLKGIEQVRVHWLLD 87

Human    96 LVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLA 160
            |||....    |.|:||.||.::|||..|.|:||||||||.||:||||||||||.||::|:...|
 Frog    88 LVTVSAK----LQYDFTKLDTFIDLLMANGLVPGFELMGSPSGYFTDFEDKQQVMEWRNLIFRTA 148

Human   161 RRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSF 225
            :|||.:|||..||:||||||||||:|||||||:|:.||.||||||||||:.|||.|..||||||.
 Frog   149 QRYIKKYGLLQVSQWNFETWNEPDNHDFDNVSVTINGFQNYYDACSEGLKQASPLLTFGGPGDSC 213

Human   226 HTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKVRPAPPSAPVFCALSRCAPGRADPGG 290
            .:|||||:.|.||.||::|||:||||.||||:||:||:|
 Frog   214 RSPPRSPICWSLLEHCYNGTNYFTGEKGVRLNYIALHKK-------------------------- 252

Human   291 AEAAPPAGCAQLHLHPGAGEGRRAADPAALPQVRGHPHLQRRGGPAGGLVPATAVEGGRDLRGHG 355
                            |||......:    .::.....:|:| .|....||.           :.
 Frog   253 ----------------GAGGSFYILE----QEMETVNEIQKR-FPLFKNVPI-----------YN 285

Human   356 GEGGPAQRPARPPATFLPRRDRRAVAAPPGPSCPGHPQVIAQHQNLLLANTTSAFPYALLSNDNA 420
            .|..|....:.|.:.   |.|....|..        .::|.||.. ||:|.:::..|:|||||||
 Frog   286 DEADPLVGWSTPQSW---RGDVTYAAMV--------VKIIDQHLQ-LLSNKSNSINYSLLSNDNA 338

Human   421 FLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSN- 484
            |:::|||.|:|||||||||:|||.|||||::||||||.||.||||.|.|:..||    .:.|||
 Frog   339 FMNFHPHYFSQRTLTARFQMNNTNPPHVQMVRKPVLTVMGFLALLGEVQISTEV----LITDSNA 399

Human   485 ---HTVGVLASAHRPQGP--ADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRY 544
               :.:|.:.|.|.|:..  ||:|::.:|.|||||.:..|..: ::|:.:...|....|||||.|
 Frog   400 KNSNIIGAIGSTHEPEKGELADSWQSTILCYASDDNKTSPTIN-SITVNMTNFPKSKDLVYVTYY 463

Human   545 LDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHV 609
            |||.|.:|..||:::|.|.|||.:||:::|..|||:...|...|..|.|.|:..|.:||:.|:|:
 Frog   464 LDNNLTNPFVEWQKVGSPDFPTIKQFQQIRDMEDPIRKGPIAFPKDGNLLLKVQLPIPSVFLIHI 528

Human   610 CARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLF 674
            |.:|...|.:||.|..||||:|::.::|||||:.|:||.|:|::||:.|..|..:::|.:.||||
 Frog   529 CEKPHSAPNKVTGLHFLPLTKGEVAVIWSDEHITSRCLKTFEVEFSETGSTYGRINKKDTMFNLF 593

Human   675 VFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLE 709
            :|||::..|||||||||::||..||.:|.|..|.|
 Frog   594 IFSPESAVVSGSYRVRAINYWDVPGLYSLPQQYTE 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDUA	XP_054205907.1	Glycosyl hydrolases	30..594	CDD:474034	258/568 (45%)
		FN3	<616..>719	CDD:442628	48/94 (51%)
idua	XP_002935502.3	Glycosyl hydrolases	24..512	CDD:474034	258/566 (46%)