DRSC/TRiP Functional Genomics Resources

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Protein Alignment borr and CDCA8

DIOPT Version :10

Sequence 1:NP_723450.1 Gene:borr / 34245 FlyBaseID:FBgn0032105 Length:319 Species:Drosophila melanogaster
Sequence 2:NP_060571.1 Gene:CDCA8 / 55143 HGNCID:14629 Length:280 Species:Homo sapiens


Alignment Length:318 Identity:74/318 - (23%)
Similarity:117/318 - (36%) Gaps:87/318 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 KMDSRLISIDSLETK----FLSAVDHQVKTLLGQVQ-------KELAN------LKMPEVLRLFE 76
            |..||:...:||..:    ||...|.:|:..:.|::       ||:.|      |::|:.||...
Human     5 KGSSRVAKTNSLRRRKLASFLKDFDREVEIRIKQIESDRQNLLKEVDNLYNIEILRLPKALREMN 69

  Fly    77 ELDRFSDFKASDQTQLLASMSMSGSAIEGHAPSATGSRNDEGYLTEDSSIGASGGSILAAHTGSL 141
            .||.|                    |:.|:..:...:...:..:||.:.:.|             
Human    70 WLDYF--------------------ALGGNKQALEEAATADLDITEINKLTA------------- 101

  Fly   142 LRSTKAMRTPGPLHSARARR--------ARRSRSACGDLNILHSAK----PP------SISSSSS 188
                :|::|  ||.||:.|:        .........:...|.:|:    ||      ||.....
Human   102 ----EAIQT--PLKSAKTRKVIQVDEMIVEEEEEEENERKNLQTARVKRCPPSKKRTQSIQGKGK 160

  Fly   189 SSRNSRSKLRTPMASRAKAFSADRTPLKQKQMRSGSPTTPPMAFLRYPKPGE--VALSKYGSPMV 251
            ..|:||:...||...|.:......||....:..|....||.   ||.|..||  ..:|..|||:.
Human   161 GKRSSRANTVTPAVGRLEVSMVKPTPGLTPRFDSRVFKTPG---LRTPAAGERIYNISGNGSPLA 222

  Fly   252 AQVMPDKFANVNIPIRNGVLSLRPKKLDADEVESNLLENLDEDTLNQIKTLHENLQMI 309
                ..|...:.:|:..|. |||   |.|.:::.:.:..||.:.|..||.|...|..|
Human   223 ----DSKEIFLTVPVGGGE-SLR---LLASDLQRHSIAQLDPEALGNIKKLSNRLAQI 272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
borrNP_723450.1 Borealin 196..312 CDD:463127 33/116 (28%)
CDCA8NP_060571.1 Required for interaction with SENP3. /evidence=ECO:0000269|PubMed:18946085 1..140 33/173 (19%)
Required for centromere localization 1..88 22/102 (22%)
Required for interaction with INCENP. /evidence=ECO:0000269|PubMed:17956729 1..58 13/52 (25%)
Required to form a minimal CPC core complex that localizes to the central spindle and midbody and properly executes the role of the CPC during cytokinesis 10..109 25/137 (18%)
Required for interaction with INCENP and BIRC5. /evidence=ECO:0000269|PubMed:17956729 20..78 16/77 (21%)
Nbl1_Borealin_N 20..76 CDD:463095 15/75 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..169 9/38 (24%)
Borealin 163..275 CDD:463127 36/121 (30%)

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