DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment borr and Cdca8

DIOPT Version :9

Sequence 1:	NP_723450.1	Gene:	borr / 34245	FlyBaseID:	FBgn0032105	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001020221.1	Gene:	Cdca8 / 500545	RGDID:	1566306	Length:	288	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	77/327 - (23%)
Similarity:	122/327 - (37%)	Gaps:	86/327 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NSKRNREVA------NREEKVRLYELKMDSRLISIDSLETKFLSAVDHQVKTLLGQVQK--ELAN 65
            |:.|:|::|      :||.:||..:::.|.                    :|||.:|:.  .:..
  Rat    14 NTLRSRKLASFLKDFDREVQVRTKQIESDR--------------------QTLLKEVENLYNIEV 58

  Fly    66 LKMPEVLRLFEELDRFS--------DFKASDQTQLLASMSMSGSAIEGHAPSATGSR---NDEGY 119
            |::|:.|::.:.||.|:        :..|:....:....:::..||:....|....:   .||..
  Rat    59 LRLPKALQVMKWLDYFALGGNRQALEEAATADRDITEINNLTAEAIQTPLKSVKKRKVIEVDEAI 123

  Fly   120 LTEDSSIGASGGSILAAHTGSLLRSTKAMRTPGPLHSARARRARRSRSACGDLNILHSAKPPSIS 184
            ..|:......||.      |...:|.|.:|      |||.:|.                 |||..
  Rat   124 KEEEEDEEEEGGG------GGGRKSHKNLR------SARVKRC-----------------PPSKK 159

  Fly   185 SSSSSSRNSRSK-----LRTPMASRAKAFSADRTPLKQKQMRSGSPTTPPMAFLRYPKPGEVA-- 242
            .:.|....||||     ..||..||.:......||....:..|....||.   ||.|...|..
  Rat   160 RTQSIQGRSRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFKTPG---LRTPAAKEQVYN 221

  Fly   243 LSKYGSPMVAQVMPDKFANVNIPIRNGVLSLRPKKLDADEVESNLLENLDEDTLNQIKTLHENLQ 307
            :|..|||:.    ..|..::::||..|. |||....|...|:   :..|:.:.|..||.|...|.
  Rat   222 ISINGSPLA----DSKEISLSVPIGGGA-SLRLLASDLQRVD---IAQLNPEALGNIKKLSSRLA 278

  Fly   308 MI 309
            .|
  Rat   279 QI 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
borr	NP_723450.1	Borealin	196..312	CDD:287483	34/121 (28%)
Cdca8	NP_001020221.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..149		32/166 (19%)
		Required for centromere localization. /evidence=ECO:0000250	1..88		19/93 (20%)
		Required for interaction with INCENP. /evidence=ECO:0000250	1..58		13/63 (21%)
		Required to form a minimal CPC core complex that localizes to the central spindle and midbody and properly executes the role of the CPC during cytokinesis. /evidence=ECO:0000250	10..109		22/114 (19%)
		Required for interaction with INCENP and BIRC5. /evidence=ECO:0000250	20..78		16/77 (21%)
		Nbl1_Borealin_N	22..76	CDD:287425	16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..173		19/77 (25%)
		Borealin	168..283	CDD:287483	37/124 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16040
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100