DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and ARNT2

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	NP_055677.3	Gene:	ARNT2 / 9915	HGNCID:	16876	Length:	717	Species:	Homo sapiens

Alignment Length:	880	Identity:	164/880 - (18%)
Similarity:	278/880 - (31%)	Gaps:	288/880 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AATAAAQTANLAAALQRSAAIMNAVASPISAN------SANSATSGRKIRRK------TDSKVNL 233
            |..||.....:|:.:..|..:   ..:|::|.      .|..|..|:  ||.      .|.:...
Human     2 ATPAAVNPPEMASDIPGSVTL---PVAPMAATGQVRMAGAMPARGGK--RRSGMDFDDEDGEGPS 61

  Fly   234 PQSQINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTST------KPDKAAILNQVVRTYREIC 292
            ..|:.|....|:|||.....||.:||         ||..|      ||||..||...|
Human    62 KFSRENHSEIERRRRNKMTQYITELS---------DMVPTCSALARKPDKLTILRMAV------- 110

  Fly   293 DKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSST 357
                         ::..|...|.|.                      :||...
Human   111 -------------SHMKSMRGTGNK----------------------STDGAY------------ 128

  Fly   358 EPPLPEPSLLLGQVPEISAYFEALEHYI--SGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELY 420
                 :||.|..|         .|:|.|  :..|::.:.....|.:...:.::..::...:.|.:
Human   129 -----KPSFLTEQ---------ELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWF 179

  Fly   421 HQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNA-S 484
            ...||..::..|..||...:.|..|:                        :.|.:.:|..|.. .
Human   180 GSTLYEQVHPDDVEKLREQLCTSENS------------------------MTGRILDLKTGTVKK 220

  Fly   485 QGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTSSNCEEKPL------RQSGHQDK 543
            :|..||..        ...|.:||...::|               |...||      |.:..:.:
Human   221 EGQQSSMR--------MCMGSRRSFICRMR---------------CGNAPLDHLPLNRITTMRKR 262

  Fly   544 YEEVVLIAAPVKDDADASSSVLCL----------ITRPEDESPL-------------------EI 579
            :...:   .|||:.....:.|.|.          :|.||:::.:                   .:
Human   263 FRNGL---GPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPV 324

  Fly   580 NIQQHVQQQPIEQMTFKLDIHGKILTLDPTALR----EPFKQHLQTWVGRLWQDLCHPHDLSTLK 640
            .:..:....|.|.:: :.:..|.|..:||..:.    :|     |..:|:...:.|||.|    :
Human   325 CMDMNGMSVPTEFLS-RHNSDGIITFVDPRCISVIGYQP-----QDLLGKDILEFCHPED----Q 379

  Fly   641 SHLRD-IQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQT 704
            ||||: .|.......       .|:|..:|.|....: ::.::.:|..|.|....|.::|:...|
Human   380 SHLRESFQQVVKLKG-------QVLSVMYRFRTKNRE-WMLIRTSSFTFQNPYSDEIEYIICTNT 436

  Fly   705 LLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSL------------LSSLSMD-------- 749
            .:.......:........||....| :..|.|:|.:.:            :.|...|
Human   437 NVKQLQQQQAELEVHQRDGLSSYDL-SQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFA 500

  Fly   750 GLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQ 814
            |:........||:.||              |.||.....|...:...|...||::::..|:...|
Human   501 GISASEKKMMSSASAA--------------GTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQ 551

  Fly   815 QQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSG-GVGAWTD 878
            .........|..|...|....|:|.|..|    |.|.     .|.:.||..:..|.| |......
Human   552 SSSSTGQNMSQISRQLNQSQVAWTGSRPP----FPGQ-----QIPSQSSKTQSSPFGIGTSHTYP 607

  Fly   879 SRPNSRASVATPVSTPRPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNF 943
            :.|:|.:.:::|.::  .|||:.:|           .|::.:.....|.||:     |.:.|
Human   608 ADPSSYSPLSSPATS--SPSGNAYS-----------SLANRTPGFAESGQSS-----GQFQG--- 651

  Fly   944 HSFDSSDVKPEKDVQQQQNQ---QQSNNNSSSSNP 975
                    :|.:...|.|:|   |||....|...|
Human   652 --------RPSEVWSQWQSQHHGQQSGEQHSHQQP 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	19/56 (34%)
		PAS	377..442	CDD:214512	11/66 (17%)
		PAS_11	591..711	CDD:291273	27/124 (22%)
ARNT2	NP_055677.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		9/40 (23%)
		bHLH-PAS_ARNT	62..124	CDD:381517	23/112 (21%)
		PAS	137..243	CDD:395786	23/152 (15%)
		PAS_11	336..436	CDD:405306	26/117 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..717		38/169 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900