Protein Alignment tai and CLOCK

DIOPT Version :10

• Sequence 1: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Sequence 2: NP_004889.1
• Gene: CLOCK / 9575
• HGNCID: 2082
• Length: 846
• Species: Homo sapiens
• Alignment Length: 1264
• Identity: 215/1264 - (17%)
• Similarity: 370/1264 - (29%)
• Gaps: 527/1264 - (41%)

  Fly   237 QINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTSTKPDKAAILNQVV---RTYREICDKGQ-- 296
            ::::..:||:||:..|..|::|..:|..|.|      |.||:.:|.:.:   |.::||..:..
Human    36 RVSRNKSEKKRRDQFNVLIKELGSMLPGNAR------KMDKSTVLQKSIDFLRKHKEITAQSDAS 94

  Fly   297 --NRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVSSTEP 359
              .:|...|..:|...|
Human    95 EIRQDWKPTFLSNEEFT------------------------------------------------ 111

  Fly   360 PLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELYHQPL 424
                 .|:|          |||:.:       .|.:..:|.|...::::..|:.:...:|..|.:
Human   112 -----QLML----------EALDGF-------FLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSI 154

  Fly   425 YMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQGSNS 489
            :.::..|:|:::..|::|        :...:::..|               |.|.:.|..:....
Human   155 FNFIPEGEHSEVYKILST--------HLLESDSLTP---------------EYLKSKNQLEFCCH 196

  Fly   490 SGAGGLGGAGGAAAGKKRSISTKVRML--VKDTRTATQTSSNCEEKPLRQSGHQDKYEEVVLIAA 552
            .       ..|....|:.|....|:.:  .|...:.:.::.|..|..:::: |:..||:.|...|
Human   197 M-------LRGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRT-HRPSYEDRVCFVA 253

  Fly   553 PVKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHGKILTLD----PTALRE 613
            .|:.........:|.:                  ::|.|:.|.:..:..|.|.||    |.....
Human   254 TVRLATPQFIKEMCTV------------------EEPNEEFTSRHSLEWKFLFLDHRAPPIIGYL 300

  Fly   614 PFKQHLQTWVGRLWQDLCHPHDLSTL-KSHLRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDV 677
            ||:.     :|....|..|..||..| |.|...:|         .|.|.|...|    .|.....
Human   301 PFEV-----LGTSGYDYYHVDDLENLAKCHEHLMQ---------YGKGKSCYYR----FLTKGQQ 347

  Fly   678 YVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSL 742
            ::.::.:..:..:|.....:||:...|:: |..::.:.....    ||:.:        ||..
Human   348 WIWLQTHYYITYHQWNSRPEFIVCTHTVV-SYAEVRAERRRE----LGIEE--------SLPE-- 397

  Fly   743 LSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIING 807
                        |.:..|                     |..|..|...|.|:
Human   398 ------------TAADKS---------------------QDSGSDNRINTVSL------------ 417

  Fly   808 TGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSGG 872
                                   ...:..|..||.|:..|
Human   418 -----------------------KEALERFDHSPTPSASS------------------------- 434

  Fly   873 VGAWTDSRPNSRASVATPVSTP--------RPPSGHGFSPAVCASPATPYQLSSHSAASLPSPQS 929
                ..||.:|..:|:.|.|||        .||..|               |.:|
Human   435 ----RSSRKSSHTAVSDPSSTPTKIPTDTSTPPRQH---------------LPAH---------- 470

  Fly   930 NASAGGGNYGGFNFHSFDSSDVKPEKDVQQQQN-QQQSNNN----SSSSNPLLGGG----LPNG- 984
                                    ||.||::.: ..||.|:    ||.:.|::...    :|.|
Human   471 ------------------------EKMVQRRSSFSSQSINSQSVGSSLTQPVMSQATNLPIPQGM 511

  Fly   985 --------VGGMLLSQQQQQQQTPPQQQQQQQQQESSERLRHLLTKSQSMAGGLGGLGDDEKYFK 1041
                    :|.|...:.|.:|:|...:....:||   |.||.:..:.|.:.|
Human   512 SQFQFSAQLGAMQHLKDQLEQRTRMIEANIHRQQ---EELRKIQEQLQMVHG------------- 560

  Fly  1042 PEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSSMLHKAGNSQNPMLLKLLNEKSEDDD 1106
                                .|:.||....:.|...|:..:  .:|||.|...|..:|.:.:...
Human   561 --------------------QGLQMFLQQSNPGLNFGSVQL--SSGNSSNIQQLAPINMQGQVVP 603

  Fly  1107 GN--GSGGGPGSMNNSRQSELMRQLKNPDGGSHGMHRNSASGNMSTEDLKAMLKIQSDPSLNRKR 1169
            .|  .||...|.:..::.   |.|.:.....|....:|..||:.....|.:..:......|....
Human   604 TNQIQSGMNTGHIGTTQH---MIQQQTLQSTSTQSQQNVLSGHSQQTSLPSQTQSTLTAPLYNTM 665

  Fly  1170 SLNEPDDDPSAKRSEDKPSKLCTQNKMLAKLLQNPPKIPKAPNPEQPLQVKTLPD---------- 1224
            .:::|                     ....::|.|..:|:  |..|...|.|...
Human   666 VISQP---------------------AAGSMVQIPSSMPQ--NSTQSAAVTTFTQDRQIRFSQGQ 707

  Fly  1225 ------ITSSTVSSTLAAP-----GNLISAGSTGPKAAANRNRKQQQQ-----QQQQQQQQQQQQ 1273
                  :|:......:..|     |.:::|..|      ...::||.|     ||||||..|:||
Human   708 QLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPT------FATQQQQSQTLSVTQQQQQQSSQEQQ 766

  Fly  1274 VAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILGE 1338
            :..:      |||:...|:|..||.||:.:|                              :.|.
Human   767 LTSV------QQPSQAQLTQPPQQFLQTSRL------------------------------LHGN 795

  Fly  1339 GDSELSKLLDSVMEYYPDDTPIVTNAPSEASAINDIQKSLMLDVESAAFGNDLNQQLMMTQQQQH 1403
            ..::|                                      :.||||  .|.|...  .|..|
Human   796 PSTQL--------------------------------------ILSAAF--PLQQSTF--PQSHH 818

  Fly  1404 QQQQQQQQLLALQLAQQQQQQRQQHLQQP 1432
            ||.|.|||       ||..:.|...|..|
Human   819 QQHQSQQQ-------QQLSRHRTDSLPDP 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	bHLH_SF	239..291	CDD:469605	15/54 (28%)
		PAS	377..442	CDD:214512	12/64 (19%)
		PAS_11	590..711	CDD:464214	28/125 (22%)
CLOCK	NP_004889.1	bHLH-PAS_CLOCK	29..89	CDD:381577	17/58 (29%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785	32..47		2/10 (20%)
		PAS	109..>175	CDD:395786	16/143 (11%)
		PAS_11	274..377	CDD:464214	27/121 (22%)
		Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785	371..845		134/786 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..411		6/61 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..495		27/152 (18%)
		Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785	450..570		35/204 (17%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564		13/85 (15%)
		SP1-4_N	550..>694	CDD:425404	32/204 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..654		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..783		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	811..846		13/39 (33%)