DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tai and Ncoa3

DIOPT Version :9

Sequence 1:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster
Sequence 2:	XP_017447775.1	Gene:	Ncoa3 / 84584	RGDID:	620109	Length:	1404	Species:	Rattus norvegicus

Alignment Length:	1820	Identity:	366/1820 - (20%)
Similarity:	580/1820 - (31%)	Gaps:	674/1820 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 ATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRG-DMTSTKPDKAAI 280
            ||..||.:...|:     ..|....:.||.|||.|:.|||:|:|:::.|... |..:.||||.||
  Rat    13 ATESRKRKLPCDA-----PGQGLVYSGEKWRREQESKYIEELAELISANLSDIDNFNVKPDKCAI 72

  Fly   281 LNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCS 345
            |.:.||..|:|  |.|.:.|||                    :::..|...:||  .:...|..|
  Rat    73 LKETVRQIRQI--KEQGKTISS--------------------DDDVQKADVSST--GQGVIDKDS 113

  Fly   346 IHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRD 410
            :.|                 |||          :||:.:       |..||.:|.|...::|:..
  Rat   114 LGP-----------------LLL----------QALDGF-------LFVVNRDGNIVFVSENVTQ 144

  Fly   411 LIGYEKQELYHQPLYMYLYSGDHAK-LEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGD 474
            .:.|::::|.:..:|..|:..|... |:.:..:..|..:..|.|.
  Rat   145 YLQYKQEDLVNTSVYSILHEQDRKDFLKHVPKSTVNGVSWTNENQ-------------------- 189

  Fly   475 LEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVK------DTRTATQTSSNCEEK 533
                                          :::|.:...|||:|      ||..:.:|
  Rat   190 ------------------------------RQKSHTFNCRMLMKTHDILEDTNASPET------- 217

  Fly   534 PLRQSGHQDKYEEVVLIA-----APVKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQM 593
                   :.:||.:...|     |.:::..|....::|:..|...:.|...:.:..:.:.
  Rat   218 -------RQRYETMQCFALSQPRAMLEEGEDLQCCMICVARRVTTDRPFPSSPESFITRH----- 270

  Fly   594 TFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHDLS--TLKSHLRDIQDSASANSPG 656
                |:.||::.:|..:||...:...:..:.|..|.....:|..  :.|.|.::......|.:|
  Rat   271 ----DLSGKVVNIDTNSLRSSMRPGFEDTIRRCIQRFFSLNDGQSWSQKRHYQEAYIHGHAETP- 330

  Fly   657 AGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSENDMNSSNTGAGS 721
                      .:|..| |....|..:..|:||.|....:....:|...|...:|....:....|.
  Rat   331 ----------VYRFSL-ADGTIVSAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGCRPNPNPVGQ 384

  Fly   722 GGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGGLVGGGQQGGG 786
            |.......|.|:.|||.:..:|.|
  Rat   385 GIRPPAAGCGMSLSPSQSVQMLGS----------------------------------------- 408

  Fly   787 GNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASPAPAEHSFYGS 851
                :|..|..|       :.||        |.:||...||||    |.:.|...:....|.|.|
  Rat   409 ----RTYGVADP-------SNTG--------QMAGARYGASSS----VASLTPGQSLQSPSSYQS 450

  Fly   852 DTFEFDIAA--HSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRPP-SGHGFSPAVCASPATP 913
            :::..::::  |.|.       |:|      ||.:..:.:|.:...|. :.|.|||
  Rat   451 NSYGLNMSSPPHGSP-------GLG------PNQQNIMISPRNRGSPKMASHQFSP--------- 493

  Fly   914 YQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVK---------------------PEKDV 957
                   ||.:.||..::    ||.|.   |||.||.:.                     |:.|.
  Rat   494 -------AAGVHSPMGSS----GNTGS---HSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDN 544

  Fly   958 QQQQNQQQSNNNSS--SSNPLLGGGLPNGVGGMLLSQQ--------QQQQQTPPQQQQQQQQQES 1012
            ....|..|.:..||  |.:||          |:...|.        ...:..|..::.::...|:
  Rat   545 SPNMNINQPSKASSQDSKSPL----------GLYCEQNPVESSVCPSNSRDHPSDKENKENSGEA 599

  Fly  1013 SE------------RLRHLLTKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGFKMGGQPGGMG 1065
            ||            :|..|||.|          .||..:.....|..:.:..........|.|:.
  Rat   600 SETPRGPLESKGHKKLLQLLTCS----------SDDRGHSSLTNSPLDSNCKDSSISVTSPSGVS 654

  Fly  1066 MFGPMGSMGRGVGNSS------------MLHKA---GNSQNPMLLKLLNEKSEDDDGNGSGGGPG 1115
                 .|....|.::|            :|||.   |||. ..:.|:..|.:..|..:.:.||.|
  Rat   655 -----SSTSGAVSSTSNMHGSLLQEKHRILHKLLQNGNSP-AEVAKITAEATGKDTSSTASGGEG 713

  Fly  1116 SMNNSRQS-------ELMRQL---------------KNPDGGSHGMHRNSASGNMSTEDLKAMLK 1158
            |:...:.|       .|:|.|               ...|||...:.:.|.|.|.|:..
  Rat   714 SVRQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQADGGDSKLSQCSCSTNPSSGQ------ 772

  Fly  1159 IQSDPSLNRKRS--------------------------LNEPDD--DPSAKRSE-DKPSKLCTQ- 1193
             :.||.:..:.|                          .|.|.:  .|.||:.. ..||.|..:
  Rat   773 -EKDPKIKTEASEEVHFQVSGDLDNLDAILGDLTSSDFYNSPTNGSHPGAKQQMFAGPSSLGLRS 836

  Fly  1194 -----------NKMLAKLLQNPPKIPKAPN----------PEQPLQV------------------ 1219
                       |:.|:  |.:|..:...|.          |:||:..
  Rat   837 PQPVQSVRPPYNRALS--LDSPVSVGSVPPVKNVSAFPVLPKQPILAGNPRMMDSQENYGANMGG 899

  Fly  1220 --KTLP-DITSST----------------VSSTLAAPGNLISA-------GSTGPKAAANRNR-- 1256
              :.:| :.|||:                .||.|...|...||       ||:||......||
  Rat   900 PNRNVPVNPTSSSGDWGLANSRASRMEPLASSPLGRAGGDYSAALPRPALGSSGPTLPLRSNRLP 964

  Fly  1257 ----------KQQQQQQQQQQQQQQQQV----AG--------------IPSQQQQQQPNDVYLSQ 1293
                      :.|||||||||||||||:    ||              :||.|....|..: ||.
  Rat   965 GARPTLQPQPQPQQQQQQQQQQQQQQQMLQMRAGEVPMGMGVSPYSPAVPSNQPGSWPEGM-LSM 1028

  Fly  1294 QQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSVMEYYPDDT 1358
            :     |.|..| |::.|...:...:....|..           ||.|:...|||.:       .
  Rat  1029 E-----QGPHGA-QNRPLLRNSLDELLGPPSNP-----------EGQSDERALLDQL-------H 1069

  Fly  1359 PIVTNAPSEASAINDIQKSLMLDVESAAFGNDLNQQLMMTQQQQHQQQQQQQQLLALQLAQQQQQ 1423
            .:::|  ::|:.:.:|.::|           .:.:.:...|..:.:|...|.|..|:.:.|:...
  Rat  1070 TLLSN--TDATGLEEIDRAL-----------GIPELVSQGQALESKQDVFQGQEAAVMMDQKAAL 1121

  Fly  1424 QRQQHLQQPPAYPGMLNMQQQQHQQQQQQNQQHIMQRLEAMRNQGNQGFQRPPPMYPARGRGPMN 1488
            ..|.:..|.|...|..::|.|.             ..|.:|.:|.:|           :|..|:.
  Rat  1122 YGQTYPAQGPPLQGGFHLQGQS-------------PSLNSMMSQISQ-----------QGSFPLQ 1162

  Fly  1489 AVATPGGVVLPAQQQLRNIRQQQQLAAAQQKERLLQQQQKQQLLVPENASEYWGNSNLQLIIKLI 1553
            .:.....:|.|.....:.:|.|.|           |:.|.||.|         ..|...|.:|
  Rat  1163 GLHPRASMVRPRTNTPKQLRMQLQ-----------QRLQGQQFL---------NQSRQALEMK-- 1205

  Fly  1554 VSYILAGMNAGLNNIGSLLNTTGAPNVSLSRTNLPS-----DAQLSPNFAQTLMQQQLSPGRSAP 1613
                             :.:.|||   ::.|..|.|     :||::....:.||...|...|.|.
  Rat  1206 -----------------MESPTGA---AVMRPMLQSQQAFFNAQMAAQQKRELMNHHLQQQRMAM 1250

  Fly  1614 YSPQPNQGYAPQ--FPQPGQRLSPQQQQQLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSG 1676
            ...||.    ||  .|.|....||.....|:.........||.               |:.:|.|
  Rat  1251 MMSQPQ----PQAFSPPPNVTASPSMDGVLAGSAMPQAPPQQF---------------PYATNYG 1296

  Fly  1677 MQSPGMQNSPQQWGSGGGGGGGPGGPL-----PSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQ 1736
            |..|     |:.  :.|.|...|...:     ||.||   :.||            |..|..||.
  Rat  1297 MGQP-----PEP--AFGRGSSPPSAMMSSRMGPSQNA---MVQH------------PQTAPMYQS 1339

  Fly  1737 NQRRGLNSPGAV----------GPGGNPAAQAALQRQNSFQGQGGGGATTPDGSGVGFGGPQSPY 1791
            ::.:|..|....          .|..||||...:...:|....|....|....||:.. ||...|
  Rat  1340 SEMKGWPSGNLARNGSFPQQQFAPQANPAAYNMVHMNSSGSHLGQMTMTPMPMSGMPM-GPDQKY 1403

Fly 1792 1791
Rat 1404 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tai	NP_001245949.1	HLH	235..286	CDD:238036	21/51 (41%)
		PAS	377..442	CDD:214512	14/65 (22%)
		PAS_11	591..711	CDD:291273	23/121 (19%)
Ncoa3	XP_017447775.1	bHLH_SF	33..102	CDD:412148	30/90 (33%)
		PAS	117..172	CDD:214512	16/71 (23%)
		PAS_11	264..374	CDD:405306	23/130 (18%)
		NCOA_u2	453..566	CDD:406952	33/158 (21%)
		SRC-1	610..698	CDD:400955	20/103 (19%)
		DUF4927	716..807	CDD:406644	14/97 (14%)
		Nuc_rec_co-act	1056..1102	CDD:400942	11/65 (17%)
		PABP-1234	<1197..1303	CDD:130689	33/151 (22%)
		DUF1518	1271..1328	CDD:400033	16/81 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10684
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030