DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tai and Ncoa2

DIOPT Version :9

Sequence 1:NP_001245949.1 Gene:tai / 34242 FlyBaseID:FBgn0041092 Length:2047 Species:Drosophila melanogaster
Sequence 2:NP_114010.1 Gene:Ncoa2 / 83724 RGDID:620108 Length:1465 Species:Rattus norvegicus


Alignment Length:1869 Identity:385/1869 - (20%)
Similarity:580/1869 - (31%) Gaps:675/1869 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 ISANSANSATSGR-KIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRG-DMT 271
            :|....|::...| :.|::.:....|..|.  |.:.|||.||.||.|||:|:|::..|... |..
  Rat     1 MSGMGENTSDPSRAETRKRKECPDQLGPSP--KRSTEKRNREQENKYIEELAELIFANFNDIDNF 63

  Fly   272 STKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRC 336
            :.||||.|||.:.|:..|:|  |.|.:..::                                  
  Rat    64 NFKPDKCAILKETVKQIRQI--KEQEKAAAA---------------------------------- 92

  Fly   337 SRCATDNCSIHPVQQGEVSSTEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGII 401
                    :|..||:.:||||...:.:.. .||.:     ..|||:.:       ...||..|.:
  Rat    93 --------NIDEVQKSDVSSTGQGVIDKD-ALGPM-----MLEALDGF-------FFVVNLEGNV 136

  Fly   402 ESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAK----LEPIINTMYNNPNGGNSNSANNSGPGG 462
            ...::|:...:.|.::||.::.:|..|:.|||.:    |.|  .:|.|               ||
  Rat   137 VFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLP--KSMVN---------------GG 184

  Fly   463 SSAGTSAGVWGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTATQTS 527
            |..|...                                   ::.|.:...|||||....:.   
  Rat   185 SWTGEPP-----------------------------------RRNSHTFNCRMLVKPLPDSE--- 211

  Fly   528 SNCEEKPLRQSGHQDKYEEVVLIAA----PVKDDA-DASSSVLCLITR-PEDESPLEINIQQHVQ 586
               ||....|..|| |||.:...|.    .:|::. |..|.::|:..| |..|.|         .
  Rat   212 ---EEGHDNQEAHQ-KYETMQCFAVSQPKSIKEEGEDKQSCLICVARRVPMKERP---------A 263

  Fly   587 QQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHD---LSTLKSHLRDIQD 648
            ....|..|.:.|:.|||..||.:.:|:..|...:..|.|..|.....|:   ||..|.|..::..
  Rat   264 LPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLR 328

  Fly   649 SASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSEN--D 711
            ...|           .|:.:|..| :....|..:..|:|..:||..|...::|:..|...:|  .
  Rat   329 QGLA-----------FSQIYRFSL-SDGTLVAAQTKSKLIRSQTTNEPQLVISIHMLHREQNVCV 381

  Fly   712 MNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLLGG 776
            ||...||...|            .|      ||.:            ||||||...|.       
  Rat   382 MNPDLTGQAMG------------KP------LSPM------------SSSSPARQAMC------- 409

  Fly   777 LVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAFTASP 841
                     .||..|..::|..:  :..:||. .:|......|.|.|...:              
  Rat   410 ---------SGNPGQDVALGSNM--NFPMNGP-REQMSMPMGRFGGSGGMN-------------- 448

  Fly   842 APAEHSFYGSDTFEFDIAAHSSSFE-LDPSGGVGAWTDSRPNSRASVATPVSTPRPPSG-----H 900
                               |.|..: ..|.|...|...:.|    |.::|...|..||.     |
  Rat   449 -------------------HVSGMQATTPQGSNYALKMNSP----SQSSPGLNPGQPSSVLSPRH 490

  Fly   901 GFSPAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDV-------------- 951
            ..||.|..||..|....| .|.||.||....|:.|      |.||:.:|.:              
  Rat   491 RMSPGVAGSPRVPPSQFS-PAGSLHSPAGVCSSTG------NSHSYTNSSLNALQALSEGHGVSL 548

  Fly   952 -----KPEKDVQQQQNQQQSNN-------NSSSSNPLLG--GGLPNGVGGMLLSQQQQQQQTPPQ 1002
                 .|:..:...||...:.|       .|..|....|  |....|..|...:....::|..|.
  Rat   549 GPSLASPDLKMGNSQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAQASCHPEEQKRPN 613

  Fly  1003 -----QQQQQQQQESSERLRH----------LLTKSQSMAGGLGGLGDDEKYFKPEG-SEEEKHA 1051
                 |...:.:.|...||..          |.|||..|          |....|.. |:..|.:
  Rat   614 DSSMPQAASEDRAEGHSRLHESKGQTKLLQLLTTKSDQM----------EPSPLPSSLSDTNKDS 668

  Fly  1052 SGGFKMGGQPGGMGMFGPMGSMGRGVGNS-SMLHK-AGNSQNPMLLKLLNEKSEDDDGN--GSGG 1112
            :|...           ||..:.|..:... .:||: ..:|.:|:.|..|..::...:.|  .||.
  Rat   669 TGSLP-----------GPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGT 722

  Fly  1113 GPGS---------MNNSRQSELMRQLKNPDGGSHGMHRNSASGNMSTEDL--------KAMLKIQ 1160
            .|||         ....:::.|:|.|.:.|               .|:|:        ...|..:
  Rat   723 APGSEVTVKQEPASPKKKENALLRYLLDKD---------------DTKDIGLPEITPKLERLDSK 772

  Fly  1161 SDPSLNRK----RSLN-----EPDDDPSAKRS-------------------EDKP-------SKL 1190
            :||:.|.|    :::.     ||.|.|.::..                   :.:|       .|.
  Rat   773 TDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQ 837

  Fly  1191 CTQNKMLAKLLQNPPKIP----KA---------------------PNPEQPLQVKTL-------- 1222
            ...|.::.....:.|..|    ||                     ||...||.: ||        
  Rat   838 AIINDLMQLTADSSPVTPVGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDI-TLQSPTGAGP 901

  Fly  1223 -PDITSSTVSSTLAAPGNLISAG-----------STG-----------------PKAAANR---- 1254
             |.|.:|:..|.:..||.:.:.|           |||                 |::.|.|    
  Rat   902 FPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRSSMPSGEWAPQSPAVRVTCA 966

  Fly  1255 ------NRKQQ--------------QQQQQQQQQQQQQQVAGI-PSQQQQQQPNDVYLSQQQQQQ 1298
                  ||..|              ...|..|:|..|.||..| ||:.:.......|..||....
  Rat   967 ATTGAMNRPIQGGMIRNPTASIPMRANSQPGQRQMLQPQVMNIGPSELEMNMGGPQYNQQQAPPN 1031

  Fly  1299 LQSP---------QLAFQHQQLATTATTSITTAASTSAAAAAAAAILGEGDSELSKLLDSVMEYY 1354
            ..:|         |.:|..|......::.........||         |..|:...|||.:  |.
  Rat  1032 QTAPWPESILPIDQASFGSQNRHPFGSSPDDLLCPHPAA---------ESPSDEGALLDQL--YL 1085

  Fly  1355 P----------DDTPIVTNAPSEASAINDIQ-----KSLMLDVESAAFGNDLNQQLMMTQQQQHQ 1404
            .          |....:....|::.|::..|     .|:||:.:...|......|..|.|...:.
  Rat  1086 ALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQESSMMLEQKPPVFPQQYASQTQMAQGSYNP 1150

  Fly  1405 QQQQQQQLLALQLAQQQQQQRQQHLQQPPA---------YPGMLNMQQQQHQQQQQQNQQHIMQR 1460
            .|......:.     |:.......:|..|.         .|..|.: |.||:.|.|||:|.:|.:
  Rat  1151 MQDPNFHTMG-----QRPNYTTLRMQPRPGLRPTGIVQNQPNQLRL-QLQHRLQAQQNRQPLMNQ 1209

  Fly  1461 LEAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQQKE----R 1521
            :..:.|                    :|....||   :|.|..:     ..|:.|.:|:|    .
  Rat  1210 ISGVSN--------------------VNLTLRPG---VPTQAPI-----NAQMLAQRQREILNQH 1246

  Fly  1522 LLQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSLSRTN 1586
            |.|:|..||..|.:.                  :.::.|.  |||...|::..||.| .::|...
  Rat  1247 LRQRQMHQQQQVQQR------------------TLMMRGQ--GLNMTPSMVAPTGLP-AAMSNPR 1290

  Fly  1587 LP-SDAQ---LSPNFAQTLMQQQLSPGRSAPYSPQPNQGY----APQFPQPGQRLSPQQQQQLSQ 1643
            :| ::||   ..||:.               .|.||:.|:    .||.|....|::..|...:.|
  Rat  1291 IPQANAQQFPFPPNYG---------------ISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQ 1340

  Fly  1644 QQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGGGGGGGPGGPLPSGNA 1708
            .|.|.      |||            |....:|            |..|..||..          
  Rat  1341 SQANP------AYQ------------PASDING------------WAQGSMGGNS---------- 1365

  Fly  1709 GRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGLNSPGAVGPGGNPAAQAALQRQNSFQGQ-GGG 1772
              ...|.:|....|....|.|       |....:|...|....|       |...|...|| ...
  Rat  1366 --MFSQQSPPHFGQQANTSMY-------NNNMNINVSMATNTAG-------LSNMNQMTGQMSMT 1414

  Fly  1773 GATTPDGSGVGFGGPQSPYGTNVNVFQQQQLQRLQRQGSVPQATQHLPG 1821
            ..|:...||:...||             :|:.....:||....|..|||
  Rat  1415 SVTSVPTSGLSSMGP-------------EQVNDPALRGSSLFTTNQLPG 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
taiNP_001245949.1 HLH 235..286 CDD:238036 23/51 (45%)
PAS 377..442 CDD:214512 17/68 (25%)
PAS_11 591..711 CDD:291273 31/124 (25%)
Ncoa2NP_114010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 10/40 (25%)
HLH 35..88 CDD:197674 26/54 (48%)
PAS 119..215 CDD:279347 31/160 (19%)
PAS 123..213 CDD:238075 27/154 (18%)
PAS_11 268..378 CDD:291273 30/121 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..528 27/89 (30%)
NCOA_u2 463..587 CDD:293270 32/134 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 547..741 41/214 (19%)
SRC-1 640..709 CDD:285981 19/89 (21%)
LXXLL motif 1 641..645 0/3 (0%)
LXXLL motif 2 690..694 2/3 (67%)
CASP8AP2-binding 691..743 11/51 (22%)
Interaction with ARNTL. /evidence=ECO:0000250|UniProtKB:Q61026 730..1121 72/417 (17%)
DUF4927 731..816 CDD:292896 15/99 (15%)
LXXLL motif 3 745..749 1/3 (33%)
LXXLL motif 4 878..882 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1075 3/31 (10%)
Nuc_rec_co-act 1071..1116 CDD:285967 9/46 (20%)
LLXXLXXXL motif 1079..1087 4/9 (44%)
DUF1518 1281..1338 CDD:284808 17/72 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1330 5/18 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341479
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 108 1.000 Inparanoid score I4820
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10684
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.980

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